

FOLLOWUS
1. 1Department of Gastroenterology, the Affiliated Nanhua Hospital of University of South China, Hengyang 421002, Hunan, China.
2. 2Department of Nephrology,the Affiliated Nanhua Hospital of University of South China, Hengyang 421002, Hunan, China.
3. 3Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
*Corresponding author Tel: 86-13874934270, Fax: 86-734-8358399, E-mail: yxf9988@126.com
Published Online:20 March 2016,
Published:2016-03
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Gao Fan, Yang Xue-feng, Fu Nian, et al. Roles of Long-chain Acyl Coenzyme A Synthetase in Absorption and Transport of Fatty Acid△[J]. Chinese medical sciences journal, 2016, 31(1): 62-64.
Long-chain acyl coenzyme A synthetase (ACSL) is a member of the synthetase family encoded by a multigene family; it plays an important role in the absorption and transport of fatty acid. Here we review the roles of ACSL in the regulating absorption and transport of fatty acid
as well as the connection between ACSL and some metabolic diseases.
Ellis JM , Frahm JL , Li L , et al . Acyl-coenzyme A synthetases in metabolic control . Curr Opin Lipidol 2010 ; 21 : 212 - 7 .
Mashek DG , Li L , Coleman RA . Long-chain acyl-CoA synthetases and fatty acid channeling . Future Lipidol 2007 ; 2 : 465 - 76 .
Jia Z , Moulson CL , Pei Z , et al . FATP4 is the principal very long-chain fatty acyl CoA synthetase in skin fibroblasts . Biol Chem 2007 ; 10 : 1074 - 88 .
Li QG , Zhu T , Yang YZ , et al . Advance research of ACSL . Chin Anim Husbandry Veter Med 2012 ; 6 : 137 - 40 .
Mashek DG , Li L , Coleman RA . Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet . Lipid Res 2006 ; 47 : 2004 - 10 .
Abumrad NA , Davidson NO . Role of the gut in lipid homeostasis . Physiol Rev 2012 ; 92 : 1061 - 85 .
Ellis JM , Mentock SM , Depetrillo MA , et al . Mouse cardiac acyl coenzyme A synthetase 1 deficiency impairs fatty acid oxidation and induces cardiac hypertrophy . Mol Cell Biol 2011 ; 31 : 1252 - 62 .
Li L , Ellis JM , Paich H , et al . Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition . Biol Chem 2009 ; 284 : 27816 - 26 .
James PH , Katie E , Yoon KL , et al . Eicosanoids in metabolic syndrome . Adv Pharmacol 2013 ; 66 : 157 - 266 .
Heimerl S , Moehle C , Zahn A , et al . Alterations in intestinal fatty acid metabolism in inflammatory bowel disease . Biochim Biophys Acta 2006 ; 1762 : 341 - 50 .
Klaus C , Jeon MK , Kaemmerer E , et al . Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind . World J Gastroenterol 2013 ; 19 : 7369 - 73 .
Soupene E , Frans A , Kuypers M . Long-chain acyl-CoA synthetases . Exp Biol Med (Maywood) 2008 ; 233 : 507 - 21 .
Tong F , Black PN , Coleman RA , et al . Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases . Arch Biochem Biophys 2006 ; 447 : 46 - 52 .
Bu SY , Mashek DG . Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways . J Lipid Res 2010 ; 51 : 3270 - 80 .
Richards MR , Harp JD , Ory DS , et al . Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes . J Lipid Res 2006 ; 47 : 665 - 72 .
Qi RL , Huang JX , Yang FY , et al . Fatty acid transport proteins and fatty acid transfer . Chin J Anim Nutr 2013 ; 5 : 905 - 11 .
Mashek DG , Coleman RA . Cellular fatty acid uptake: the contribution of metabolism . Curr Opin Lipidol 2006 ; 17 : 274 - 8 .
Yan S , Yang XF , Liu HL , et al . Long-chain acyl-CoA synthe- tase in fatty acid metabolism involved in liver and other diseases: an update . World J Gastroenterol 2015 ; 21 : 3492 - 8 .
Poppelreuther M , Rudolph B , Du C , et al . The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake . J Lipid Res 2012 ; 53 : 888 - 900 .
Filip-Ciubotaru F , Foia L , Manciuc C , et al . PPARs: structure, mechanisms of action and control. Note I . Rev Med Chir Soc Med Nat Iasi 2011 ; 115 : 477 - 84 .
Li LO , Klett EL , Coleman RA . Acyl-CoA synthesis, lipid metabolism and lipotoxicity . Biochim Biophys Acta 2010 ; 1801 : 246 - 51 .
Mashek DG , McKenzie MA, Van Horn CG, et al. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle -RH7777 cells . Biol Chem 2006 ; 281 : 945 - 50 .
Tripathy D , Mohanty P , Dhindsa S , et al . Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects . Diabetes 2003 ; 52 : 2882 - 7 .
Wu D , Liu JT , Pang XM , et al . Palmitic acid exerts proinflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthanse and tumor necrosis factor-α . Int J Mol Med 2014 ; 34 : 1706 - 12 .
Liu JT . The progress of atherosclerosis inflammation me- chanism . Academic J Xi’an Jiaotong Univ (Med Sci) 2015 ; 2 : 141 - 52 .
Kageyama A , Matsui H , Ohta M , et al . Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-κB, novel targets of eicosapentaenoic acid . PLoS One 2013 ; 8 : e681 - 97 .
Golej DL , Askari B , Kramer F , et al . Long-chain acyl-CoA synthetase 4 modulates prostaglandin E 2 release from human arterial smooth muscle cells . J Lipid Res 2011 ; 52 : 782 - 93 .
Kanter JE , Kramer F , Barnhart S , et al . Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1 . Proc Natl Acad Sci USA 2012 ; 109 : E715 - E24 .
Kim JA , Monyagnani M . Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms . Circulation 2006 ; 113 : 1888 - 904 .
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