Objective To assese the healing of stoma after magnetic anastomosis for the reconstruction of biliary-enteric continuity under severe inflammation.Methods Acute bile duct injury was constructed as a bile peritonitis model in mongrel dogs (n=32). Magnetic anastomosis (group A

n=16) and traditional suture anastomosis (group B

n=16) were performed to reconstruct the biliary-enteric continuity in one stage. Half of the dogs in each group were euthanized on the 30th postoperative day

and the other half on the 90th postoperative day to harvest the stoma region. The healing conditions of the stoma after the 2 anastomotic approaches were observed with naked eyes

under light microscope and scanning electron microscope.Results The stoma leakage rate (50% versus 0% on the 30th postoperative day

37.5% versus 12.5% on the 90th postoperative day

both P<0.05) and stenosis degree (13.9%±0.3% versus 7.1%±0.3% on the 30th postoperative day

17.2%±0.4% versus 9.4%±0.4% on the 90th postoperative day

both P<0.01) were significantly higher in group B than in group A. Compared with traditional manual anastomoses

the histological analysis under light and electron microscope showed a more continuous stoma with more regular epithelium proliferation and collagen arrangement

less inflammation in group A.Conclusions Magnetic anastomosis stent ensures better healing of the stoma even under the circumstance of severe inflammation.