Impact of 1, 25-(OH)2D3 on Left Ventricular Hypertrophy in Type 2 Diabetic Rats△

Fan Ying; Zhang Shan-xiao; Ren Meng; Hong Li-feng; Yan Xiao-ni

Your Location：

Home >

Browse articles >

Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△

Chinese Medical Sciences Journal Vol. 30, Issue 2, Pages: 114-120(2015)

Original Articles | Updated：2024-04-10

- Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△
- Affiliations：
  
  1. 1Department of Cardiology, the Fifth Hospital of Wuhan & Institute of Cardiovascular Sciences of Jianghan University, Wuhan 430050, China;
  2. 2Department of Cardiology, the First Hospital of Yangtze University,Jingzhou, Hubei 434000, China
- Author bio：
  
  * Corresponding author Tel: 86-27-84812640, E-mail: leefenghong@gmail.com
- Funds：
- DOI：
  CLC：
- Received：12 February 2014，
  
  Published Online：20 April 2015，
  
  Published：2015-04
- Accepted：
Scan QR Code
Fan Ying, Zhang Shan-xiao, Ren Meng, et al. Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△[J]. Chinese medical sciences journal, 2015, 30(2): 114-120.
DOI：

Fan Ying, Zhang Shan-xiao, Ren Meng, et al. Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△[J]. Chinese medical sciences journal, 2015, 30(2): 114-120. DOI：

摘要

Abstract

Objective

To investigate the impact of 1

25-(OH)

on left ventricular hypertrophy (LVH) in type 2 diabetic rats.

Methods

Type 2 diabetic mellitus (DM) model rats were established by intraperitoneally injecting with 30 mg/kg streptozotocin. After 8 weeks

19 male rats were identified as diabetic with left ventricular hypertrophy (LVH) by ultrasound examination

and randomly assigned into three groups: untreated (DM-LVH

=7)

treated with insulin (DM-LVH+INS

=6)

and treated with 1

25-(OH)

(DM-LVH+VD

=6). Healthy male rats were used as the controls group (

=6). The fasting blood glucose and the insulin level were determined weekly. The left ventricular mass index

myocardial collagen content

collagen volume fraction

and 1

25-(OH)

-receptor level were determined by 4 weeks later.

Results

In the DM-LVH model group

the insulin level was significantly decreased compared with the non-diabetic control group (

0.05)

whereas the blood glucose

left ventricular mass index

myocardial collagen content

collagen volume fraction

and 1

25-(OH)

-receptor expression were significantly increased (all

0.05). In the DM-LVH+INS and DM-LVH+VD groups

the insulin levels were significantly increased compared with the DM-LVH model group (

0.05)

whereas the other parameters were significantly decreased (all

0.05).

Conclusion

25-(OH)

could reverse LVH in diabetic rats and that the mechanism may involve stimulating insulin secretion and reducing blood glucose

via

direct up-regulation of 1

25-(OH)

-receptor expression.

关键词

Keywords

references

Boudina S , Abel ED. Diabetic cardiomyopathy revisited. Circulation 2007 ; 115 : 3213 - 23 .

Fang ZY , Prins JB , Marwick TH. Diabetic cardiomyopathy: Evidence, mechanisms, and therapeutic implications. Endocr Rev 2004 ; 25 : 543 - 67 .

Rubler S , Dlugash J , Yuceoglu YZ , et al. New type of cardiomyopathy associated with diabetic glomerulos- clerosis. Am J Cardiol 1972 ; 30 : 595 - 602 .

Eguchi K , Boden-Albala B , Jin Z , et al. Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic population. Am J Cardiol 2008 ; 101 : 1787 - 91 .

Dawson A , Morris AD , Struthers AD. The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus. Diabetologia 2005 ; 48 : 1971 - 9 .

Nkum BC , Micah FB , Ankrah TC , et al. Left ventricular hypertrophy and insulin resistance in adults from an urban community in the Gambia: Cross-sectional study. PLoS One 2014 ; 9 : e93606 .

Becerra-Tomás N , Estruch R , Bullo M , et al. Increased serum calcium levels and risk of type 2 diabetes in individuals at high cardiovascular risk. Diabetes Care 2014 ; 37 : 3084 - 91 .

Song X , Bishop JE , Okamura WH , et al. Stimulation of phosphorylation of mitogenactivated protein kinase by 1alpha, 25-dihydroxy vitamin D3 in promyelocytic NB4 leukemia cells: A structure-function study. Endocrinology 1998 ; 139 : 457 - 65 .

Nemerovski CW , Dorsch MP , Simpson RU , et al. Vitamin D and cardiovascular disease. Pharmacotherapy 2009 ; 29 : 691 - 708 .

Tishkoff DX , Nibbelink KA , Holmberg KH , et al. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology 2008 ; 149 : 558 - 64 .

de Simone G , Wallerson DC , Volpe M , et al . Echo- cardiographic measurement of left ventricular mass and volume in normotensive and hypertensive rats. Necropsy validation. Am J Hypertens 1990 ; 3 : 688 - 96 .

de Simone G , Devereux RB , Wallerson DC . Echocardio- graphic assessment of left ventricular hypertrophy in rats using a simplified approach. Am J Hypertens 1994 ; 7 : 555 - 8 .

Xu Shuyun. Pharmacological experimental methodology. 2nd ed. Beijing : People's Health Press ; 1982 .

Bell DS. Diabetic cardiomyopathy. A unique entity or a complication of coronary artery disease? Diabetes Care 1995 ; 18 : 708 - 14 .

Giles TD , Ouyang J , Kerut EK , et al. Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. Am J Physiol 1998 ; 274 : H295 - 307 .

Lu X , Yang XY , Howard RL , et al. Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis. Diabetologia 2000 ; 43 : 1136 - 44 .

Tyagi SC , Hayden MR. Role of nitric oxide in matrix remodeling in diabetes and heart failure. Heart Fail Rev 2003 ; 8 : 23 - 8 .

Nishikawa N , Yamamoto K , Sakata Y , et al. Differential activation of matrix metalloproteinases in heart failure with and without ventricular dilatation. Cardiovasc Res 2003 ; 57 : 766 - 74 .

Palomer X , Gonzalez-Clemente JM , Blanco-Vaca F , et al. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab 2008 ; 10 : 185 - 97 .

Chiu KC , Chu A , Go VL , et al. Hypovitaminosis D is asso- ciated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004 ; 79 : 820 - 5 .

Borissova AM , Tankova T , Kirilov G , et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003 ; 57 : 258 - 61 .

Mattila C , Knekt P , Männistö S , et al. Serum 25-hydroxy vitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007 ; 30 : 2569 - 70 .

Pittas AG , Dawson-Hughes B , Li T , et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006 ; 29 : 650 - 6 .

Wu J , Garami M , Cao L , et al. 1, 25(OH) 2 D 3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am J Physiol 1995 ; 268 : E1108 - 13 .

Chen S , Gardner DG. Retinoic acid uses divergent mechanisms to activate or suppress mitogenesis in rat aortic smooth muscle cells. J Clin Invest 1998 ; 102 : 653 - 62 .

Chen S , Costa CH , Nakamura K , et al. Vitamin D-dependent suppression of human atrial natriuretic peptide gene promoter activity requires heterodimer assembly. J Biol Chem 1999 ; 274 : 11260 - 6 .

Xiang W , Kong J , Chen S , et al. Cardiac hypertrophy in vitamin D receptor knockout mice: Role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab 2005 ; 288 : E125 - 32 .

Bodyak N , Ayus JC , Achinger S , et al. Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci USA 2007 ; 104 : 16810 - 5 .

Uysal S , Kalayci AG , Baysal K. Cardiac functions in children with vitamin D deficiency rickets. Pediatr Cardiol 1999 ; 20 : 283 - 6 .

Park CW , Oh YS , Shin YS , et al. Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism. Am J Kidney Dis 1999 ; 33 : 73 - 81 .

Chen S , Glenn DJ , Ni W , et al. Expression of the vitamin D receptor is increased in the hypertrophic heart. Hypertension 2008 ; 52 : 1106 - 12 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰