Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study<sup>△</sup>

Tian Shu-bo; Yu Jian-chun; Kang Wei-ming; Ma Zhi-qiang; Ye Xin; Yan Chao; Huang Ya-kai

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Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△

Chinese Medical Sciences Journal Vol. 30, Issue 2, Pages: 84-89(2015)

Original Articles | Updated：2024-04-10

- Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△
- Affiliations：
  
  Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  *Corresponding author Tel: 86-10-69152215, E-mail: yu-jch@163.com
- Funds：
- DOI：
  CLC：
- Received：24 February 2015，
  
  Published Online：20 April 2015，
  
  Published：2015-04
- Accepted：
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Tian Shu-bo, Yu Jian-chun, Kang Wei-ming, et al. Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△[J]. Chinese medical sciences journal, 2015, 30(2): 84-89.
DOI：

Tian Shu-bo, Yu Jian-chun, Kang Wei-ming, et al. Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△[J]. Chinese medical sciences journal, 2015, 30(2): 84-89. DOI：

摘要

Abstract

Objective

To evaluate the prognostic effects of neoadjuvant chemotherapy (NAC) in patients with local advanced gastric cancer.

Methods

We retrospectively analyzed prognosis in 191 patients with advanced gastric cancer

of whom 71 were treated with NAC and 120 received surgery only between February 2007 and July 2013. Postoperative complication rate was recorded. Survival by clinicopathological features

pathological T and N stages

and histopathological tumor regression was retrospectively compared between the two groups.

Results

According to Response Evaluation Criteria in Solid Tumors

none of the 71 patients in the NAC followed by surgery group showed complete response

36 showed partial response

25 had stable disease

and 10 had progressive disease. The chemotherapy response rate was 50.7%; the disease control rate was 85.9%. Grade 3/4 adverse events were seen in less than 20% patients

with acceptable toxicities. No difference was found in the overall postoperative complication rates between the two groups (7

versus

22 cases

=0.18). Median survival time was significantly different

at 54 months in the NAC combined with surgery group and 25 months in the surgery-only group (

=0.025).

Conclusion

In patients with operable gastric adenocarcinomas

NAC can significantly improve overall survival without increasing surgical complications.

关键词

Keywords

references

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