Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma<sup>△</sup>

Wang Meng-yi; Niu Zhe-yu; Xiang-Gao; Zhou Li; Liao* Quan; Zhao* Yu-pei

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Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma^△

Chinese Medical Sciences Journal Vol. 31, Issue 3, Pages: 149-154(2016)

Orginal Article | Updated：2024-04-10

- Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma^△
- Affiliations：
  
  Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
- Funds：
- DOI：
  CLC：
- Published Online：20 June 2016，
  
  Published：2016-06
- Accepted：
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Wang Meng-yi, Niu Zhe-yu, Xiang-Gao, et al. Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma^△[J]. Chinese medical sciences journal, 2016, 31(3): 149-154.
DOI：

Wang Meng-yi, Niu Zhe-yu, Xiang-Gao, et al. Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma^△[J]. Chinese medical sciences journal, 2016, 31(3): 149-154. DOI：

摘要

Abstract

Objective

To examine the expression of cell division cycle associated 2 (CDCA 2) in pancreatic ductal adenocarcinoma (PDAC) and investigate its role in prognosis of PDAC patients.

Methods

This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues. Clinicopathological characteristics between high and low CDCA2 expression were compared. Correlation of CDCA2 expressions with patients’ survival was analyzed using Kaplan-Meier method and Cox regression analysis.

Results

Expression of CDCA2 in PDAC cells was significantly higher than that in adjacent non-tumor tissues (

=4056.5

0.001). Univariate analysis showed that CDCA2 expression [hazard ratio (

)=1.574

95% confidence interval (

)=1.014-2.443

=0.043] and node metastasis (

=1.704

95%

=1.183-2.454

=0.004) were significantly associated with prognosis. Cox regression analysis showed CDCA2 expression was not an independent prognostic risk factor (

=1.418

95%

=0.897-2.242

=0.135) for PDCA patients. Stratification survival analysis demonstrated CDCA2 expression as an independent prognostic risk factor in male patients (

=2.554

95%

=1.446-4.511

=0.003) or in non-perineural invasion patients (

=2.290

95%

=1.146-4.577

=0.012).

Conclusions

CDCA2 is highly expressed in PDAC tumor tissue. Although CDCA2 is not an independent prognostic risk factor for PDAC patients

it might be used to help predict prognosis of male or non-perineural invasion patients of PDAC.

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references

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