Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma<sup>△</sup>

Nie Ke-ke; Geng Chuan-xin; Zhang Ling; Liu Shi-chao; Zhang Zhong-fa; Wang Rong; Zou Xiao; Ji You-xin

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Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma^△

Chinese Medical Sciences Journal Vol. 31, Issue 4, Pages: 221-227(2016)

Orginal Article | Updated：2024-04-10

- Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma^△
- Affiliations：
  
  1. 1Department of Oncology, Qingdao Cancer Hospital, Qingdao, Shandong 266042, China
  2. 2ndDepartment of Oncology, Qingdao Central Hospital, 2nd Affiliated Hospital of Qingdao University, Qingdao,Shandong 266042, China
- Author bio：
  
  *Corresponding author Tel: 86-532-68665078, Fax: 86-532-84852500, E-mail: 123456789ji@gmail.com,niekekeqd@163.com
- Funds：
- DOI：
  CLC：
- Published Online：20 August 2016，
  
  Published：2016-08
- Accepted：
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Nie Ke-ke, Geng Chuan-xin, Zhang Ling, et al. Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma^△[J]. Chinese medical sciences journal, 2016, 31(4): 221-227.
DOI：

Nie Ke-ke, Geng Chuan-xin, Zhang Ling, et al. Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma^△[J]. Chinese medical sciences journal, 2016, 31(4): 221-227. DOI：

摘要

Abstract

Objective

To investigate the clinical effects and safety of bevacizumab combined with S-1 as the second-line treatment of recurrent and/or metastatic esophageal cancer after chemoradiation.

Methods

Patients with recurrent or metastatic esophageal cancer after chemoradiation were treated with bevacizumab and S-1. Bevacizumab was used by intravenous infusion

7.5mg/kg body weight on day 1; S-1 was used by oral at 80mg/m

·d on day 1-14

21 days as a cycle of treatment and repeated until either pro- gressive disease or intolerable toxicity occurred. Chest CT were performed and RECIST 1.1 was used for response evaluation. Kaplan-Meier method was used for survival analysis. Side effects were recorded and analyzed.

Results

Totally 78 patients were enrolled in the study

including 67 squamous cell carcinoma and 11 adenocarcinoma histologically. The overall response (CR+PR) rate was 22.4% (17/76) and disease control (CR+PR+SD) rate was 61.8% (47/76) respectively. The median follow-up time was 20 months (range from 9 to 44 months). The median progression-free survival (PFS) was 4.9 months (95%

4.4-5.5) and the median overall survival (OS) was 8.1 months (95%

7.6-9.2). The median PFS and OS of patients with metastasis diseases were 6.2 months (95%

3.3 to 6.3) and 8.5 months (95%

5.8 to 11.2)

where PFS was longer than that of patients with local regional recurrence (median 5.0 months

95%

3.0 to 5.5

=0.017) and OS was longer than that of patients with regional disease and metastasis (median 8.0 months

95%

4.6 to 9.5

=0.010). The common adverse effects were mild to moderate neutropenia (84.2%)

grade I-II hand and foot syndrome (51.3%)

grade I-II nausea (48.7%)

mild epistaxis (30.1%) and mild vomiting (14.5%). Esophageal bleeding occurred in 7.9% of patients. One patient (1.3%) died from massive bleeding which was caused by esophageal perforation.

Conclusion

Bevacizumab combined with S-1 was effective and safe for esophageal cancer patients who had recurrent or metastatic diseases after chemoradiation.

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Keywords

references

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