Objective To investigate the effects of alcohol intake on penile structure and function in rats. Methods Thirty adult male Wistar rats were randomly divided into two groups: control group and alcohol intake group. They were administered with 2 mL of normal saline and 40% alcohol solution respectively through gastric tubes every day. Three months later

the animal model of alcohol intake was evaluated by modified Nayagida’s method

and the effects of alcohol on the rats were studied by sexual behavior

the number of apomorphine-induced penile erection

level of testosterone in the sera

and the content of penile smooth muscle. Results The scores of animal model of alcohol intake evaluated by Nayagida’s method were 0.66±2.05 in the control group and 9.26±5.50 in the alcohol intake group（P<0.05）

which indicated that an animal model of alcohol intake was successfully established. Sexual behavior

the number of apomorphine-induced penile erection

testosterone level in the sera

and the content of penile smooth muscle of the alcohol intake group were all statistically different as compared with the control group（P<0.05）. Conclusion Alcohol intake induces sexual dysfunction in rats

which may be due to the decline of testosterone level in the sera and decline of penile smooth muscle.