Objective To investigate the correlation between serum resistin level

cardiovascular risk factors and severity of coronary disease in acute coronary syndrome （ACS）. Methods After evaluated by clinical history

electrocardiography

exercise tolerance tests

laboratory tests

and coronary angiography

220 consecutive patients with suspected chest pain were divided into normal control group

stable angina pectoris （SAP） group

and ACS group

respectively. Baseline clinical characteristics

including height

weight

waist circumference

hip circumference

white blood cell count

high-sensitive C-reactive protein （hsCRP）

total cholesterol

triglyceride

low-density lipoprotein cholesterol and high-density lipoprotein cholesterol

were compared among three groups. ELISA was used to detect serum resistin levels. Pearson’s correlation coefficient analysis was used to assess association between resistin and other traditional cardiovascular risk factors. Multinomial logistic regression analyses were used to define the relationship between serum resistin level and SAP or ACS. Results Serum resistin level in ACS group （1.18±0.48 μg/L） was significantly higher than that in normal control and SAP groups （0.49±0.40 and 0.66±0.40 μg/L; P<0.01）. Only in ACS group

increased serum resistin level was significantly correlated with hsCRP （r=0.262

P=0.004） and white blood cell count （r=0.347

P=0.001）. Furthermore

serum resistin levels showed a stepwise increase with the number increase of > 50% stenosed coronary vessels. Multinomial logistic regression test demonstrated that serum resistin was a strong risk factor for ACS （OR=29.132

95%CI: 10.939-77.581

P<0.001）. Conclusion These findings suggested the potential role of resistin in atherosclerosis and especially its involvement in ACS.