SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS

Ying Qi; Yan-ping Ma; Rong He; Zheng-rong Sun; Yao-hua Ji; Yu-jing Huang; and Qiang Ruan Virus Laboratory; Shengjing Hospital; China Medical University; Shenyang 110004

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SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS

Chinese Medical Sciences Journal Issue 1, Pages: 23-27(2008)

Updated：2024-04-10

- SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（30170986）
- DOI：
  CLC： R373
- Published：2008
- Accepted：
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[1].SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS[J].Chinese Medical Sciences Journal,2008(01):23-27.

Ying Qi, Yan-ping Ma, Rong He, et al. SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS[J]. Chinese medical sciences journal, 2008, (1): 23-27.
[1].SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS[J].Chinese Medical Sciences Journal,2008(01):23-27. DOI：

Ying Qi, Yan-ping Ma, Rong He, et al. SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS[J]. Chinese medical sciences journal, 2008, (1): 23-27. DOI：

摘要

Objective To investigate the variability of human cytomegalovirus（HCMV）UL140 open reading frame（ORF）in clinical strains

and to explore the relationship between the variability of UL140 ORF and different symptoms of HCMV infection.Methods HCMV UL140 ORF was amplified by polymerase chain reaction and sequenced selectedly in 30 clinical strains.Results UL140 ORF of all clinical strains was amplified successfully.Compared with that of Toledo strain

the nucleotide and amino acid sequence identities among all strains were 96.5%-100.0% and 95.2%-100.0%

respectively.All of the nucleotide changes were substitutions.The post-translational modification sites were conserved.The result of phylogenetic tree showed that the strains did not cluster according to different clinical symptoms.Conclusion HCMV UL140 ORF in clinical strains is highly conserved

which may play an important role in HCMV infection.

Abstract

Objective To investigate the variability of human cytomegalovirus（HCMV）UL140 open reading frame（ORF）in clinical strains

the nucleotide and amino acid sequence identities among all strains were 96.5%-100.0% and 95.2%-100.0%

which may play an important role in HCMV infection.

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