Objective To investigate the clinical characteristics and treatment strategy of lower extremity arterial occlusive disease in patients with Crohn’s disease （CD）. Methods Clinical information of 9 cases suffering from lower extremity arterial occlusion and CD was investigated retrospectively. Results All the cases were less than 50 years old and the most were females （8/9）. Arterial occlusions occurred in either active （5/9） or inactive （4/9） stage of CD. Besides the arteries of lower extremities

other arteries could also be involved such as aorta

iliac artery

renal artery or mesentery artery. Seven cases had atherosclerotic imaging findings （4 had aortic plaques and 6 had iliac artery stenoses）. Embolectomy or thromboendarterectomy were mostly performed. Four （44.4%） cases had recurrent lower limb ischemia. Conclusions Arterial occlusive disease is a rare extraintestinal manifestation of CD. A thorough inspection of aorta is necessary. Embolectomy is mostly preferred. Anticoagulation treatment is highly recommended after the operation.