Objective To investigate the relationship between pemphigus vulgaris （PV） and human leukocyte antigen （HLA） in Han nation of northeast China. Methods Standard microcytotoxicity test and polymerase chain reaction-sequence specific primers method were used to detect the HLA classⅠ antigens and HLA-DRB1 and DQB1 alleles in 27 patients with PV and results were compared with control group. Results Gene and phenotype frequencies of HLA-A3

A26（10）

B60（40）

and B13 （27.99%

48%; 16.11%

30%; 23.02%

41%; 16.11%

30%

respectively） increased significantly in PV group compared with control （1.01%

2%; 0.5%

1%; 4.61%

9%; 5.13%

10%

respectively）. After P value correction

the difference of A3

A26 （10）

and B60 （40） between the two groups was still significant. The gene frequencies of HLA-DRB1*140x （1401

1404

1405

1407

1408）

DRB1*120x

and DQB1*0503 alleles in PV group （42.26%

25.46%

and 23.02%） were significantly higher than control group （5.09%

7.74%

and 1.89%）. After P value correction

the difference was still significant between the two groups. Conclusion PV significantly relates with HLA in PV patients of Han nation of northeast China.