Objective The -455 G/A（HaeIII）polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of ischemic cerebrovascular disease. Methods We accumulated 134 acute ischemic cerebrovascular disease（ICVD）cases and compared their -455 G/A status with a control group（n = 166）. The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeIII. Results Plasma fibrinogen was higher in AA homozygous participants（341 mg/dL）than in partici-pants carrying the G allele: GA（290 mg/dL）

GG（298 mg/dL）in the control group. Plasma fibrinogen was also higher in AA homozygous patients（353 mg/dL）than in cases carrying the G allele: GA（287 mg/dL）

GG（302 mg/dL）in the ICVD group. However

there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded

β-fibrinogen gene -455 G/A polymor-phism is an independent predictor of plasma fibrinogen

but not of ischemic cerebrovascular disease.