PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO

Your Location：

Home >

Browse articles >

PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO

Chinese Medical Sciences Journal Issue 2, Pages: 67-74(2003)

Updated：2024-04-10

- PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO
- Affiliations：
  
  1. Department of Cardardiology
  2. the First Affiliated Hospital
  3. Nanjing Medical University
  4. ,China
  5. The Program in Brain & Behavior and Division of Neurology
  6. The Hospital for Sick Children and Department of Physiology
  7. University of Toronto
  8. University Avenue,555
  9. Ontario
  10. Canada M5G IX8
- Author bio：
- Funds：
  
  This work was supported by an operaing grant and a scholarship from the Medical Research Council of Canada（MRC）and by a start-up fund from the Hospital for Sick Children Research Institute to L,Y.W.
- DOI：
  CLC： R339.16
- Published：2003
- Accepted：
Scan QR Code
[1]桂鸣,Lu-YangWang.PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO[J].Chinese Medical Sciences Journal,2003(02):67-74.

PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO[J]. Chinese medical sciences journal, 2003, (2): 67-74.
[1]桂鸣,Lu-YangWang.PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO[J].Chinese Medical Sciences Journal,2003(02):67-74. DOI：

PROPERTIES OF VOLTAGE-GATED SODIUM CHANNELS IN DEVELOPING AUDITORY NEURONS OF THE MOUSE IN VITRO[J]. Chinese medical sciences journal, 2003, (2): 67-74. DOI：

摘要

正

Objective. To investigate the properties of voltage-gated sodium （Na+） channels in developing auditory neurons during early postnatal stages in the mammalian central nervous system.Methods. Using the whole-cell voltage-clamp technique

we have studied changes in the electrophysi-ological properties of Na+ channels in the principal neurons of the medial nucleus of the trapezoid body （MNTB）.Results. We found that MNTB neurons already express functional Na+ channels at postnatal day 1 （P1）

and that channel density begins to increase at P5 when the neurons receive synaptic innervation and reach its maximum （

fold） at P11 when functional hearing onsets. These changes were paralleled by an age-dependent acceleration in both inactivation and recovery from inactivation. In contrast

there was very little alteration in the voltage-dependence of inactivation.Conclusion. These profound changes in the properties of voltage-gated Na+ channels may increase the excitability of MNTB neurons and enhance their phase-l

Abstract

and that channel density begins to increase at P5 when the neurons receive synaptic innervation and reach its maximum （

fold） at P11 when functional hearing onsets. These changes were paralleled by an age-dependent acceleration in both inactivation and recovery from inactivation. In contrast

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰