ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS

Hui-min Liu1; 2; Jing-xin Li1; and Lian-bi Chen1 1Institute of Physiology; School of Medicine; Shandong University; Jinan 250012 2Department of Physiology; Shandong University of Traditional Chinese Medicine; Jinan 250014

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ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS

Chinese Medical Sciences Journal Issue 2, Pages: 123-127(2007)

Updated：2024-04-10

- ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS
- Affiliations：
- Author bio：
- Funds：
  
  Supported by a grant from Shandong Natural Sciences Foundation（Y2005C96）.
- DOI：
  CLC： R363
- Published：2007
- Accepted：
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[1].ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS[J].Chinese Medical Sciences Journal,2007(02):123-127.

Hui-min Liu1, 2, Jing-xin Li1, et al. ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS[J]. Chinese medical sciences journal, 2007, (2): 123-127.
[1].ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS[J].Chinese Medical Sciences Journal,2007(02):123-127. DOI：

Hui-min Liu1, 2, Jing-xin Li1, et al. ISCHEMIC PRECONDITIONING RELIEVES ISCHEMIA/REPERFUSION INJURY OF HIPPOCAMPUS NEURONS IN RAT BY INHIBITING p53 AND BAX EXPRESSIONS[J]. Chinese medical sciences journal, 2007, (2): 123-127. DOI：

摘要

Objective To examine whether ischemic preconditioning （IPC） can protect neuron against delayed death in CA1 subfield of hippocampus following reperfusion of a lethal ischemia in rats

and explore the role of p53 and bax in this process. Methods We examined the effect of IPC on delayed neuron death

neuron apoptosis

expressions of p53 and bax gene in the CA1 area of hippocampus in the rats using HE staining

flow cytometry

RT-PCR

and immunohistochemistry technique. Results IPC enhanced the quantity of survival cells in the CA1 region of hippocampus （216±9 cells/0.72 mm2 vs. 30±5 cells/0.72 mm2

P<0.01）

decreased the percentages of apoptotic neurons of hippocampus caused by ischemia/reperfusion （2.06%±0.21% vs. 4.27%±0.08%

P<0.01）

and weakened the expressions of p53 and bax gene of hippocampus compared with ischemia/reperfusion without IPC. Conclusion IPC can protect the neurons in the CA1 region of hippocampus against apoptosis caused by ische- mia/reperfusion

and this process may be related to the reduced expressions of p53 and bax.

Abstract

Objective To examine whether ischemic preconditioning （IPC） can protect neuron against delayed death in CA1 subfield of hippocampus following reperfusion of a lethal ischemia in rats

and explore the role of p53 and bax in this process. Methods We examined the effect of IPC on delayed neuron death

neuron apoptosis

expressions of p53 and bax gene in the CA1 area of hippocampus in the rats using HE staining

flow cytometry

RT-PCR

and immunohistochemistry technique. Results IPC enhanced the quantity of survival cells in the CA1 region of hippocampus （216±9 cells/0.72 mm2 vs. 30±5 cells/0.72 mm2

P<0.01）

decreased the percentages of apoptotic neurons of hippocampus caused by ischemia/reperfusion （2.06%±0.21% vs. 4.27%±0.08%

P<0.01）

and this process may be related to the reduced expressions of p53 and bax.

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