EXPRESSION OF DPC4 PROTEIN IN COLORECTAL CARCINOMA IN DIFFERENT STAGES

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EXPRESSION OF DPC4 PROTEIN IN COLORECTAL CARCINOMA IN DIFFERENT STAGES

Chinese Medical Sciences Journal Vol. 0, Issue 3, Pages: 162-166(2003)

Updated：2024-04-10

- EXPRESSION OF DPC4 PROTEIN IN COLORECTAL CARCINOMA IN DIFFERENT STAGES
- Affiliations：
  
  1. Tang Zhaohui 1, ,Zou Shengquan 1 ,Hao Youhua 2 ,Yang Xiangping 3 ,Chen Qiqi 4 and Qiu Fazu 1 1 Department of General Surgery,2 Institute of Clinical Immunology,Tongji Hospital,Tongji Medical College,H uazhong University of Science and Technology,Wuhan430030 3 Department of Biochemistry,Rheinisch-Westfalische Technische Hochschule ,D-52074Aachen,Germany 4 Department of Pathology,University of Iowa ,,42,Iowa,USA,IA522
  2. Huazhong University of Science and Technology Wuhan,430030
  3. Institute of Clinical Immunology
  4. Tongji Hospital
  5. Department of Biochemistry
  6. Rheinisch-Westfalische Technische Hochschule(RWTH) D-52074Aachen
  7. ,China
  8. Department of Pathology
  9. University of Iowa Iowa
- Author bio：
- Funds：
- DOI：
  CLC： R735.3
- Published：2003
- Accepted：
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EXPRESSION OF DPC4 PROTEIN IN COLORECTAL CARCINOMA IN DIFFERENT STAGES[J]. Chinese medical sciences journal, 2003, 0(3): 162-166.
DOI：

EXPRESSION OF DPC4 PROTEIN IN COLORECTAL CARCINOMA IN DIFFERENT STAGES[J]. Chinese medical sciences journal, 2003, 0(3): 162-166. DOI：

摘要

Abstract

Objective.To d etermine whether the non-expression of DPC4protein only occurs late in the dev el-opment of colorectal carcinoma.Methods.In this study

we examined the ex pression of DPC4protein in formalin-fixed archival specimens from102colorec tal neoplasm with immunohistochemical analysis.Those specimens were classi-fie d into5stages:stageⅠ;stageⅡ（intramucosal carcinoma

8cases）;stageⅢ（primary invasive carcinoma without infiltration of the l ymph nodes

11cases）;stageⅣ（primary invasive carcinoma with infiltration of the lymph nodes

25cases）;and stageⅤ（carcinoma metastasized to dis-ta nt tissue

22cases）.Results.The frequency of non-expression of DPC4prote ins were5.5%in stage I

12.5%in stage II;9% in stage III;36%in stage IV;32%in stag e V.The frequency of negative expression of DPC4protein were analyzed by÷ 2 test for stage II and III versus stage IV and V and there was statistically significant difference.At same time

there was statistically signifi-cant differencefor adenoma versus carcinoma .Conclusions.The frequency of non-expression of DPC4protein increases as the stage of colorectal carcinoma advances and the non-expressio n of DPC4protein is likely to be a late event in the sequential pathogenesis o f colorectal carcinoma.The non-expression DPC4protein in colorectal neoplasm may sug-gest its malignant characteristic

which will help us to increase the insight on colorectal carcinoma.

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