ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N5, N10 -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION△

Your Location：

Home >

Browse articles >

ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION^△

Chinese Medical Sciences Journal Vol. 0, Issue 4, Pages: 231-235(2002)

Updated：2024-04-10

- ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION^△
- Affiliations：
- Author bio：
- Funds：
- DOI：
  CLC： R743.3
- Published：2002
- Accepted：
Scan QR Code
ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION^△[J]. Chinese medical sciences journal, 2002, 0(4): 231-235.
DOI：

ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION^△[J]. Chinese medical sciences journal, 2002, 0(4): 231-235. DOI：

摘要

<正>To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis - ultraviolet detection and the gene polymorphism of N5

N10 - methylenetetrahydrofolate reductase (MTHFR) was studied with PCR-RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients (19. 3 ± 6. 0 μ mol/L) was markedly higher than that of the controls (13. 7 ± 5. 4μ mol/L) (t = 4. 16

P < 0. 001). There are 3 genotypes

C/C

C/T and T/T

about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However

the frequencies of each genotype and allele were not significantly different between the patients and the controls.Conclusions. The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction

and is related t

Abstract

Objective. To investigate the relationship of plasma homocysteine （Hcy） level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis - ultraviolet detection and the gene polymorphism of N5

N10 - methylenetetrahydrofolate reductase （MTHFR） was studied with PCR-RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients （19. 3 ± 6. 0 μ mol/L） was markedly higher than that of the controls （13. 7 ± 5. 4μ mol/L）（t = 4. 16

P < 0. 001）. There are 3 genotypes

C/C

C/T and T/T

about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However

and is related to the C→T mutation at locus 677 of MTHFR gene.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰