Objectives. To compare the effects of losartan

enalapril and their combination in the prevention of left ventricular remodeling （LVRM） after acute myocardial infarction （AMI） in the rat.Methods. AMI model was induced in female SD rats by ligating left coronary artery. Forty-eight hours after the procedure

83 surviving rats were randomized into one of the following 4 groups : 1) AMI control group （n = 19）

2) losartan group （n =22

3 mg · kg-1 · d-1）

3) enalapril group （n =20

1mg · kg-1· d-1）

4) losartan - enalapril combinative group （n = 22

3 and 1mg · kg-1 · d-1 respectively）. 5) sham-operated group （n = 10） and 6) normal rats group （n = 10） were selected randomly to serve as non-infarction controls. Losartan and enalapril were delivered by direct gastric gavage. After 4 weeks of medical therapy

hemodynamic studies were performed in each group

then the rat hearts were fixed with 10% formalin and pathologic analysis on them was performed. Complete experimental data was obtained in 56 rats

comprising 1) AMI controls （n = 11）

2) losartan group （n = 10）

3) enalapril group （n = 10）

4) the combination of losartan and enalapril group （n = 11）

5) sham -operated group （n = 6） and 6) normal controls （n =8）.Results. There were no significant differences among the 4 AMI groups in MI size （41. 7% - 43. 4%

all P> 0.05）. Compared with sham group

the left ventricular （LV） end diastolic pressure （LVEDP）

volume （LVV）

long and short axis length （L and D）

as well as LV absolute and relative weight （LVAW and LVRW） in AMI group were all significantly increased （ P <0. 05-0. 001）; whereas the maximum left ventricular pressure rising and droping rates （ ± dp/dt） and their corrected values by LV systolic pressure （ ± dp/dt/LVSP） were significantly reduced （all P <0. 001）

indicating LVRM occurred and LV systolic and diastolic function impaired after AMI. Compared with AMI group

LVEDP

LVV

LVAW and LVRW were all significantly decreased （ P <0. 05 -0. 001）; while ± dp/dt/LVSP were significantly enhanced in all 3 treatment groups （P <0. 05 -0. 001） except -dp/dt/LVSP in losartan group （P> 0. 05）. There were no significant differences in the above indices among the 3 treatment groups （all P> 0. 05）.Conclusion. Both losartan and enalapril can prevent from LVRM after AMI in the rat and improve LV function with equivalent effects. There seems no additive effect when the 2 drugs are used in combination.