Objective. To compare and match metabolic images of PET with anatomic images of CT and MRI. Methods. The CT or MRI images of the patients were obtained through a photo scanner

and then transferred to the remote workstation of PET scanner with a floppy disk. A fusion method was developed to match the 2- dimensional CT or MRI slices with the correlative slices of 3- dimensional volume PET images. Results. Twenty－ nine metabolically changed foci were accurately localized in 21 epilepsy patients’ MRI images

while MRI alone had only 6 true positive findings. In 53 cancer or suspicious cancer patients

53 positive lesions detected by PET were compared and matched with the corresponding lesions in CT or MRI images

in which 10 lesions were missed. On the other hand

23 lesions detected from the patients’ CT or MRI images were negative or with low uptake in the PET images

and they were finally proved as benign. Conclusions. Comparing and matching metabolic images with anatomic images helped obtain a full understanding about the lesion and its peripheral structures. The fusion method was simple

practical and useful for localizing metabolically changed lesions.