Objective. To measure the circulating levels of thrombomodulin （TM） and plasminogen activator inhibitor type- I （PAI- I） in women with pregnancy induced hypertension （PIH）. Methods. Blood samples were drawn from 97 pregnant women in their third trimester

grouped as 25 mild PIH

26 moderate PIH

22 severe PIH and 24 normotensive healthy pregnant women for determining levels of TM by ELISA

PAI- I by colorimetric assay methods

and creatinine （Cr） in serum by biochemical method. Results. Circulating levels of TM

PAI- I and TM/Cr ratio increased with increasing severity of PIH. There were no significant differences between mild and normotensive pregnant women. The parameters were significantly changed in the moderate and severe PIH groups. Conclusion. TM and PAI- I may serve as meaningful clinical markers for the assessment of the endothelial damage in PIH

which is very important in evaluating and following the development of PIH.