ASSOCIATION BETWEEN LOW- DENSITY LIPOPROTEIN   RECEPTOR- RELATED PROTEIN GENE,   BUTYRYLCHOLINESTERASE GENE AND   ALZHEIMER’S DISEASE IN CHINESE

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ASSOCIATION BETWEEN LOW- DENSITY LIPOPROTEIN RECEPTOR- RELATED PROTEIN GENE, BUTYRYLCHOLINESTERASE GENE AND ALZHEIMER’S DISEASE IN CHINESE

Chinese Medical Sciences Journal Vol. 0, Issue 2, Pages: 71-75(2001)

Updated：2024-04-10

- ASSOCIATION BETWEEN LOW- DENSITY LIPOPROTEIN RECEPTOR- RELATED PROTEIN GENE, BUTYRYLCHOLINESTERASE GENE AND ALZHEIMER’S DISEASE IN CHINESE
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  CLC： R392.12
- Published：2001
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ASSOCIATION BETWEEN LOW- DENSITY LIPOPROTEIN RECEPTOR- RELATED PROTEIN GENE, BUTYRYLCHOLINESTERASE GENE AND ALZHEIMER’S DISEASE IN CHINESE[J]. Chinese medical sciences journal, 2001, 0(2): 71-75.
DOI：

ASSOCIATION BETWEEN LOW- DENSITY LIPOPROTEIN RECEPTOR- RELATED PROTEIN GENE, BUTYRYLCHOLINESTERASE GENE AND ALZHEIMER’S DISEASE IN CHINESE[J]. Chinese medical sciences journal, 2001, 0(2): 71-75. DOI：

摘要

Abstract

Objective. To research the relations between low- density lipoprotein receptor- related protein gene （LRP） polymorphism

butyrylcholinesterase gene （BchE） polymorphism and Alzheimer’s disease （AD） in Chinese. Methods. The gene polymorphisms of LRP and BchE were genotyped in 38 AD cases and 40 controls with polymerase chain reaction- restriction fragment length polymorphism （PCR- RFLP） methods. AD groups were classified according to the LRP C/C genotype and compared with matched controls. Results. AD group had higher frequencies of C/C homozygote （81.6％ vs 60.0％

P< 0.05） and of C allele （89.5％ vs 76.3％

P< 0.05）

with no significant difference between any of these LRP genotypes classified AD groups and their respective control groups. Conclusions. A positive correlation was found between LRP gene polymorphism and AD

but not between BchE gene polymorphism and AD in Chinese AD cases.

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