Department of Etiology  and Department of Pharmacology

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Department of Etiology and Department of Pharmacology

Chinese Medical Sciences Journal Vol. 0, Issue 1, Pages: 20-23(2000)

Updated：2024-04-10

- Department of Etiology and Department of Pharmacology
- Affiliations：
- Author bio：
- Funds：
  
  This research was supported by the National Foundation ofNatural Sciences（NO.3947001）
- DOI：
  CLC： R378
- Published：2000
- Accepted：
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Department of Etiology and Department of Pharmacology[J]. Chinese medical sciences journal, 2000, 0(1): 20-23.
DOI：

Department of Etiology and Department of Pharmacology[J]. Chinese medical sciences journal, 2000, 0(1): 20-23. DOI：

摘要

Abstract

In order to understand the role of transmembrane signal transduction of host cells in the early steps of infection

the adherence of E. coli to HEp 2 cells and the change of activity of phospholipase C γ （PLC γ） induced by the adherence were investigated.The adherence of enteropathogenic E.coli （EPEC）

strain E.7

induced a significant increase of inositol triphosphat （IP 3） level in HEp 2 cells. The adherence of the bacteria and the increase of IP 3 was kinetically correlated. Whereas the increase of IP 3 level induced by the adherence of the control strain EPEC （H511）

a non piliated strain

was much meager than that by E7

a piliated strain. The results highlighted an important role of transmembrane signals like IP 3 in the pathogenesis of EPEC.

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