C-TYPE  NATRIURETIC  PEPTIDE  INHIBITS  UPREGULATION  OF  α1-ADRENOCEPTOR  AND  INOSITOL  1,4,5-TRISPHOSPHATE  RECEPTOR  IN  RAT    VASCULAR  SMOOTH  MUSCLE  AFTER  VASCULAR    ENDOTHELIAL  INJURY

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C-TYPE NATRIURETIC PEPTIDE INHIBITS UPREGULATION OF α1-ADRENOCEPTOR AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT VASCULAR SMOOTH MUSCLE AFTER VASCULAR ENDOTHELIAL INJURY

Chinese Medical Sciences Journal Vol. 0, Issue 2, Pages: 73-78(2000)

Updated：2024-04-10

- C-TYPE NATRIURETIC PEPTIDE INHIBITS UPREGULATION OF α1-ADRENOCEPTOR AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT VASCULAR SMOOTH MUSCLE AFTER VASCULAR ENDOTHELIAL INJURY
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  CLC： R334
- Published：2000
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C-TYPE NATRIURETIC PEPTIDE INHIBITS UPREGULATION OF α1-ADRENOCEPTOR AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT VASCULAR SMOOTH MUSCLE AFTER VASCULAR ENDOTHELIAL INJURY[J]. Chinese medical sciences journal, 2000, 0(2): 73-78.
DOI：

C-TYPE NATRIURETIC PEPTIDE INHIBITS UPREGULATION OF α1-ADRENOCEPTOR AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT VASCULAR SMOOTH MUSCLE AFTER VASCULAR ENDOTHELIAL INJURY[J]. Chinese medical sciences journal, 2000, 0(2): 73-78. DOI：

摘要

Abstract

Objective.In a model of balloon injury of rat aortic endothelium

the effects of C-type natriuretic peptide（CNP） on α 1-adrenoreceptor and inositol 1

5-triphosphate （IP 3） receptor were studied Methods. Aortic injuries were produced by vascular endothelium-denudation.α 1- adrenoreceptor in smooth muscle sarcolemma and IP 3 receptor in smooth muscle sarcoplasmic reticulum in the rat aorta were assayed by radioactive analysis method Results. It was found that neointima was formed and the contents of DNA

collagen and elastin of each intimamedia were significantly increased in 7 days and 21 days after balloon injury of rat aorta. α 1adrenoreceptor in smooth muscle sarcolemma and IP 3 receptor in sarcoplasmic reticulum were also upregulated. Results also showed that the administration of CNP ip significantly decreased the contents of DNA

collagen and elastin of each intimamedia

and inhibited the upregulation of α 1adrenoreceptor and IP 3 receptor Conclusion. The inhibition of the upregulation of α 1adrenoreceptor and IP 3 receptor by CNP might be one of the mechanisms of its suppressive action on intimal proliferation

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