STUDY  OF  THE  RELATIONSHIP  BETWEEN  PSORIASIS  AND THE  POLYMORPHIC  SITE  C677T OF  METHYLENETETRAHYDROFOLATE  REDUCTASE

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STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE

Chinese Medical Sciences Journal Vol. 0, Issue 2, Pages: 119-120(2000)

Updated：2024-04-10

- STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE
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  CLC： R758.63
- Published：2000
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STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE[J]. Chinese medical sciences journal, 2000, 0(2): 119-120.
DOI：

STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE[J]. Chinese medical sciences journal, 2000, 0(2): 119-120. DOI：

摘要

Abstract

Objective. In order to investigate 5

10-methylenetetrahydrofolate reductase （MTHFR）s polymorphic changes in psoriasis vulgaris. Methods.We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP. Results.Genotype frequencies of the psoriastics were C/C=20.15%

C/T=48.72% and T/T= 30.77%; the allelic frequencies were C=0.4487 and T=0.5513. Homozygous mutant （TT） of the psoriastics was significantly different from the normal control group by X2 test. Conclusion.C677V mutant of MTHFR might be related with psoriasis.

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