THE  ROLE  OF  INTRONIC  HSE  IN  THE  HEAT    SHOCK  INDUCED  EXPRESSION  OF    HUMAN  hsp  90β  GENE

Wang  Xiaozhe; Wang  Yanlin; Liu  Juhong; Wu  Ninghua  and  Shen  Yufei      (沈)    National  Laboratory  of  Medical  Molecular  Biology; Institute  of  Basic  Medical  Sciences; CAMS  &  PUMC; Beijing  100005

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THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE

Chinese Medical Sciences Journal Issue 4, (1998)

Updated：2024-04-10

- THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE
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  CLC： R364.14;Q343.1
- Published：1998
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[1].THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE[J].Chinese Medical Sciences Journal,1998(04):8-12.

Wang Xiaozhe, Wang Yanlin, Liu Juhong, et al. THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE[J]. Chinese medical sciences journal, 1998, (4).
[1].THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE[J].Chinese Medical Sciences Journal,1998(04):8-12. DOI：

Wang Xiaozhe, Wang Yanlin, Liu Juhong, et al. THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE[J]. Chinese medical sciences journal, 1998, (4). DOI：

摘要

ＩＮＴＲＯＤＵＣＴＩＯＮＨｕｍａｎｈｓｐ９０βｇｅｎｅｉｓｏｎｅｏｆｔｈｅｍｉｎｏｒｍｅｍｂｅｒｓｔｈａｔｃｏｎｔａｉｎｉｎｔｒｏｎｓｉｎｈｅａｔｓｈｏｃｋｇｅｎｅｆａｍｉｌｙ（１）．Ｈｕｍａｎｈｓｐ９０ｇｅｎｅｃｏｎｓｉｓｔｓｏｆｔｗｏｃｏｐｉｅｓ...

Abstract

The first intron of human hsp90β gene is not only essential in maintaining high constitutive expression but also critical for heat shock inducibility of the hsp90β gene. Typical HSEs in the first intron play a vital role in the heat induced expression of human hsp90β gene. Slot blot analysis shows that hsp90β gene mRNA transcripts initiated from the 3’ of the first intron dominates over that of the first exon. The intronic HSEs of the hsp90β gene show much higher binding affinity toward the recombinant heat shock factor HSF1 than that of the recombinant heat shock factor HSF2.

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