REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE (PGCL3)TRANSFECTED WITH hRAR βGENE
Chinese Medical Sciences JournalIssue 1, (1996)
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REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE (PGCL3)TRANSFECTED WITH hRAR βGENE
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CLC:R363
Published:1996
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[1]朱伟勇,吴秉铨,郑杰,方伟岗,王洁良,由江峰.REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE(PGCL3) TRANSFECTED WITH hRARβ GENE[J].Chinese Medical Sciences Journal,1996(01):13-16.
REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE (PGCL3)TRANSFECTED WITH hRAR βGENE[J]. Chinese medical sciences journal, 1996, (1).
[1]朱伟勇,吴秉铨,郑杰,方伟岗,王洁良,由江峰.REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE(PGCL3) TRANSFECTED WITH hRARβ GENE[J].Chinese Medical Sciences Journal,1996(01):13-16.DOI:
REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE (PGCL3)TRANSFECTED WITH hRAR βGENE[J]. Chinese medical sciences journal, 1996, (1).DOI:
REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE (PGCL3)TRANSFECTED WITH hRAR βGENE
The recombinant PSG5-RARβ plasmid and the G418-resistant PSV2neo Plasmid ( 10 : 1) were cotransfected into PGCL3 cells by copreciprtation with calcium phosphate. The transfectants CR3 and CR4
which expressed the RARβ gene. were identified by Northern blot hybridization. The results showed that the in vitro growth and invasion of CR3 and CR4 were dramatically reduced compared to the control-transfected cell (CSV1). Furthermore
the colony-forming abilities in soft agar and the tumorigenicrty in nude mice of CR3 and CR4 were abrogated. Our results suggests that RARβ functions not only as a receptor mediating the RA action