CLONING AND CHARACTERIZATION OF A METAL RESPONSIVE ELEMENT-CONTAINING FRAGMENT FROM THE WILSON DISEASE GENE LOCUS BY JUNCTION TRAPPING

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CLONING AND CHARACTERIZATION OF A METAL RESPONSIVE ELEMENT-CONTAINING FRAGMENT FROM THE WILSON DISEASE GENE LOCUS BY JUNCTION TRAPPING

Chinese Medical Sciences Journal Vol. 0, Issue 1, Pages: 9-13(1998)

Updated：2024-04-10

- CLONING AND CHARACTERIZATION OF A METAL RESPONSIVE ELEMENT-CONTAINING FRAGMENT FROM THE WILSON DISEASE GENE LOCUS BY JUNCTION TRAPPING
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  CLC： R363
- Published：1998
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CLONING AND CHARACTERIZATION OF A METAL RESPONSIVE ELEMENT-CONTAINING FRAGMENT FROM THE WILSON DISEASE GENE LOCUS BY JUNCTION TRAPPING[J]. Chinese medical sciences journal, 1998, 0(1): 9-13.
DOI：

CLONING AND CHARACTERIZATION OF A METAL RESPONSIVE ELEMENT-CONTAINING FRAGMENT FROM THE WILSON DISEASE GENE LOCUS BY JUNCTION TRAPPING[J]. Chinese medical sciences journal, 1998, 0(1): 9-13. DOI：

摘要

Abstract

All mammalian metallothionein genes studied to date have several metal responsive elements （MRE） with consensus sequences of TGCRCNC （R

purine） in their regulatory region. MRE-like sequences were also found in many other metal-related genes. To see whether there is also such a sequence at the genetic locus （13q14. 3） of Wilson disease

which is a genetic disorder of copper metabolism

junction-trapping method based on the MRE sequence was used. A fragment containing MRE and MRE-like sequences from YAC 27D8 at the WND locus was successfully cloned and mapped back to the YAC by PCR. Presence of such a sequence in the copper transporter gene at the WD locus might imply that it has a possible interesting role in the regulation of WD gene expression.

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