APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER’S DISEASE

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APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER’S DISEASE

Chinese Medical Sciences Journal Vol. 0, Issue 2, Pages: 123-125(1998)

Updated：2024-04-10

- APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER’S DISEASE
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- DOI：
  CLC： R749.16
- Published：1998
- Accepted：
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APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER’S DISEASE[J]. Chinese medical sciences journal, 1998, 0(2): 123-125.
DOI：

APOLIPOPROTEIN E POLYMORPHISM AND ALZHERMER’S DISEASE[J]. Chinese medical sciences journal, 1998, 0(2): 123-125. DOI：

摘要

Abstract

We determined and analysed the ApoE polymorphism of 30 sporadic Alzheimer’s disease （AD） pa- tients

27 patients with multi-infarct dementia （MID） and 46 aged healthy subjects as control. The results showed that the frequency of ApoE E4/3 genetype in AD group was significantly higher than that in con- trol （P<0. 05）. Among these three groups

ApoE 4 allele frequency in AD group was significantly higher than that in control （P<0. 01 ） and MID group （P<0. 05）. Among the three ApoE alleles

the risk ratio of ApoE E4 allele in AD group was 4. 114（p<0. 01 ）. There was statistically significant （P<0. 05） as the increasing of ApoE 4 gene dose in AD. It suggests that ApoE is related to AD of Chineses and it might be a genetics index of early diagnosis for AD.

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Related Author

赵永辉

王燕妮

祝家庆

Chao-xian Zhang

Yong-mei Qin

Li-ke Guo

Related Institution

Department of Cardiology

First Hospital

Xi′an Jiaotong University

Xi′an Jiaotong University Xi′an

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