THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE

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THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE

Chinese Medical Sciences Journal Vol. 0, Issue 3, Pages: 139-142(1997)

Updated：2024-04-10

- THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE
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  CLC： R392.2
- Published：1997
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THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE[J]. Chinese medical sciences journal, 1997, 0(3): 139-142.
DOI：

THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE[J]. Chinese medical sciences journal, 1997, 0(3): 139-142. DOI：

摘要

Abstract

The synthesis Of DNA

RNA and protein in L121O cells was inhibited by HHO7A in a dose-dependentand time-dependent way. HHO7A shOwed much stronger inhibitory effect on [3H]-thymidine incorporationthan that on [3H]-uridine or [3H]-tyrosine incorporation. The methods of shift of absorption spectrum

shift of fluorescence emission spectrum and excitation spectrum

and isotope technique were used to investigate the mechanism of actiOn of HHO7A on DNA synthesis. The results suggested thaT the action ofHHO7A on DNA synthesis was nOt probably due to direct damage to the DNA template

it might mainlyact by interfering with the metabolism of DNA.

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