EXPRESSION OF BONE MORPHOGENETIC PROTEIN-1 IN FETAL HUMAN CARTILAGE AND BONE DURING ENDOCHONDRAL OSSIFICATION

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EXPRESSION OF BONE MORPHOGENETIC PROTEIN-1 IN FETAL HUMAN CARTILAGE AND BONE DURING ENDOCHONDRAL OSSIFICATION

Chinese Medical Sciences Journal Vol. 0, Issue 3, Pages: 129-133(1998)

Updated：2024-04-10

- EXPRESSION OF BONE MORPHOGENETIC PROTEIN-1 IN FETAL HUMAN CARTILAGE AND BONE DURING ENDOCHONDRAL OSSIFICATION
- Affiliations：
- Author bio：
- Funds：
  
  National Natural Science Foundation of China
- DOI：
  CLC： R681.3
- Published：1998
- Accepted：
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EXPRESSION OF BONE MORPHOGENETIC PROTEIN-1 IN FETAL HUMAN CARTILAGE AND BONE DURING ENDOCHONDRAL OSSIFICATION[J]. Chinese medical sciences journal, 1998, 0(3): 129-133.
DOI：

EXPRESSION OF BONE MORPHOGENETIC PROTEIN-1 IN FETAL HUMAN CARTILAGE AND BONE DURING ENDOCHONDRAL OSSIFICATION[J]. Chinese medical sciences journal, 1998, 0(3): 129-133. DOI：

摘要

Abstract

The expression of mRNA for bone morphogenetic protein-1 （BMP-1） was investigated in fetal human cartilage and bone during the developing endochondral ossification by using in situ hybridization. BMP-1 mRNA was localized in the hypertrophic chondrocytes

the cells of perichondrium

osteoblasts and marrow cells. The results suggest that BMP-1 may involve in cartilage and bone formation

and in regulation of calcification of growth plate.As a comparative study

the expression of TGF-β1 protein was investigated in cartilage and bone using immunohistochemical staining

correlated expression of TGF-β1 and BMP-1 was found. The results suggest that BMP-1 and TGF-β1 act synergistically to influence endochrondral ossification.

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