Although cholecystokinin is localized within neuronal fibres of the pancreas

a physiological role for intrapancreatic cholecystokinin has not been identified. The strategy of this study was to elicit pure vagal stimulation electrically

and to use specific receptor antagonists to identify the mediators of exocrine pancreatic secretion. We conclude that vagal stimulation of the rat pancreas involves ganglionic neurotransmission and release of acetylcholine and cholecystokinin from intrapancreatic

postganglionic fibres. To our knowledge

this is the first study to demonstrate a physiological role for intrapancreatic cholecystokinin.