The polymorphism of apoE

an important determinant in the lipid metabolism

may be related to the atherosclerotic events. In this study

the apoE genotypes

by means of PCR AFLP assay in 42 patients with cortical cerebral infarction and 85 healthy controls were detected. The results showed that the apoE ε 3/3 genotype was more prevalent in the controls （55.29%）

and ε 3/4 genotype was more common in the patients （57.14%）. The frequency of ε 4 allele was more predominate in the patients than that in the controls. The ε 3/4 genotype or ε 4 allele was associated with 2.44 or 2.31 fold increase in the risk of cortical cerebral infarction. Therefore

it was suggested that apoE ε 4 allele is a genetic factor of susceptibility to cerebral infarction

which supported the hypothesis of the association between apoE polymorphism and atherosclerotic cardio cerebrovascular disorders.