Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis

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Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis

Chinese Medical Sciences Journal Issue 2, Pages: 132(1997)

Updated：2024-04-10

- Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis
- Affiliations：
  
  1. Institute of Medical Biology
  2. CAMS & PUMC
  3. Kunming International Centre for Genetic Engineering and Biotechnology,650107
  4. UNIDO
  5. ,China
- Author bio：
- Funds：
- DOI：
  CLC： R392
- Published：1997
- Accepted：
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[1]陈元鼎,Rodolfo Garcia,Sergio Tisminetzky,郭仁,Francisco E.Baralle.Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis[J].Chinese Medical Sciences Journal,1997(02):132.

Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis[J]. Chinese medical sciences journal, 1997, (2): 132.
[1]陈元鼎,Rodolfo Garcia,Sergio Tisminetzky,郭仁,Francisco E.Baralle.Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis[J].Chinese Medical Sciences Journal,1997(02):132. DOI：

Expression of HIV-1 env Glycoprotein gp120 and gp160 in Vaccinia Virus System and Their Antigenicity Analysis[J]. Chinese medical sciences journal, 1997, (2): 132. DOI：

摘要

<正> Human immunodeficiency virus type 1 （HIV-1）is the principal causative agent of AIDS which is threatening human health. The most important antigen of HIV1 is the viral envelope glycoprotein

gp160. The mature form of the HIV-1 gp160 is made up of two major regions:the extracellular （gq120） and the transmembrane （gp41） domains. The gp120 binds with high affinity to CD4. he cellular receptor for HIV-1

and antibodies that prevent the CD4-gq120 interaction are able to block HIV-1 infection. A principal neutralizing deter-

Abstract

<正> Human immunodeficiency virus type 1 （HIV-1）is the principal causative agent of AIDS which is threatening human health. The most important antigen of HIV1 is the viral envelope glycoprotein

and antibodies that prevent the CD4-gq120 interaction are able to block HIV-1 infection. A principal neutralizing deter-

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