p53 INDEPENDENT G<sub>1</sub> ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN

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p53 INDEPENDENT G₁ ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN

Chinese Medical Sciences Journal Issue 2, Pages: 71-75(1997)

Updated：2024-04-10

- p53 INDEPENDENT G₁ ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN
- Affiliations：
  
  1. Department of Surgery
  2. Molecular Biology Lab
  3. Cancer Hospital
  4. Shanghai Medical University
  5. ,China
- Author bio：
- Funds：
- DOI：
  CLC： R96
- Published：1997
- Accepted：
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[1]邵志敏,江明,余黎明,韩企夏,沈镇宙.p53 INDEPENDENT G_1 ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN[J].Chinese Medical Sciences Journal,1997(02):71-75.

p53 INDEPENDENT G₁ ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN[J]. Chinese medical sciences journal, 1997, (2): 71-75.
[1]邵志敏,江明,余黎明,韩企夏,沈镇宙.p53 INDEPENDENT G_1 ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN[J].Chinese Medical Sciences Journal,1997(02):71-75. DOI：

p53 INDEPENDENT G₁ ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN[J]. Chinese medical sciences journal, 1997, (2): 71-75. DOI：

摘要

<正> The biological activity of adriamycin was investigated in human breast carcinoma （HBC） cells. Adri-amycin inhibited the growth of a number of HBC cell lines and induced G1 arrest followed by apoptosis. In MCF-7 cells that harbor wild-type p53

adriamycin-induced G1 arrest and apoptosis was accompanied by p53-independent regulation of WAF1/CIP1 as well as bax mRNA levels. In MDA-MB-231 cells which possess a mutant p53

adriamycin-induced G1 arrest and apoptosis was also associated with a cpncomitant up-regulation of WAF1/CIP1 mRNA while these cells did not express bax or bcl-2 messages. Thus

adriamycin induces G1 arrest and apoptosis via a unique pathway which appears to involve activation of downstream effectors of p53-independent manner.

Abstract

The biological activity of adriamycin was investigated in human breast carcinoma （HBC） cells. Adri-amycin inhibited the growth of a number of HBC cell lines and induced G1 arrest followed by apoptosis. In MCF-7 cells that harbor wild-type p53

adriamycin-induced G1 arrest and apoptosis was accompanied by p53-independent regulation of WAF1/CIP1 as well as bax mRNA levels. In MDA-MB-231 cells which possess a mutant p53

adriamycin-induced G1 arrest and apoptosis was also associated with a cpncomitant up-regulation of WAF1/CIP1 mRNA while these cells did not express bax or bcl-2 messages. Thus

adriamycin induces G1 arrest and apoptosis via a unique pathway which appears to involve activation of downstream effectors of p53-independent manner.

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p53 INDEPENDENT G1 ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN

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p53 INDEPENDENT G₁ ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN