BEHAVIOR AND ACTIVITIES IN THE CENTRAL NERVOUS SYSTEM AFTER ACTIVATION OF L-TYPE CALCIUM CHANNELS IN MICE

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BEHAVIOR AND ACTIVITIES IN THE CENTRAL NERVOUS SYSTEM AFTER ACTIVATION OF L-TYPE CALCIUM CHANNELS IN MICE

Chinese Medical Sciences Journal Vol. 0, Issue 1, Pages: 1-5(1997)

Updated：2024-04-10

- BEHAVIOR AND ACTIVITIES IN THE CENTRAL NERVOUS SYSTEM AFTER ACTIVATION OF L-TYPE CALCIUM CHANNELS IN MICE
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  CLC： R14
- Published：1997
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BEHAVIOR AND ACTIVITIES IN THE CENTRAL NERVOUS SYSTEM AFTER ACTIVATION OF L-TYPE CALCIUM CHANNELS IN MICE[J]. Chinese medical sciences journal, 1997, 0(1): 1-5.
DOI：

BEHAVIOR AND ACTIVITIES IN THE CENTRAL NERVOUS SYSTEM AFTER ACTIVATION OF L-TYPE CALCIUM CHANNELS IN MICE[J]. Chinese medical sciences journal, 1997, 0(1): 1-5. DOI：

摘要

Abstract

The distribution of the immediate early gene c-fos expression in the mouse central nervous system after subcutaneous injection of Bay K 8644 was observed immunohistochemically. Half an hour after injection

cfos protein （FOS） was expressed in the piriform cortex

sensorimotor cortex

caudate putamen

thalamic paraventricular nucleus and striate cortex

etc. Intense FOS immunoreactive （FOS-ir） cells were seen during 2 ～ 4 h after injection. The restllts suggested that the distribution of FOS-ir ce1ls after subcutaneous injection of Bay K 8644 was coincldent with that of L-type calcium channels in the different areas of the CNS. After Bay K 8644 injection

mice appeared seizure-like behavior. The percentage of cells double-labelled by FOS and CaBP immunoreactivities in the observed regions was about 60. 2～72. 8% in CaBP-ir cells. It suggested that most CaBP-lr cells may have L-type calcium channels.

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Tang Zhaohui 1, ,Zou Shengquan 1 ,Hao Youhua 2 ,Yang Xiangping 3 ,Chen Qiqi 4 and Qiu Fazu 1 1 Department of General Surgery,2 Institute of Clinical Immunology,Tongji Hospital,Tongji Medical College,H uazhong University of Science and Technology,Wuhan430030 3 Department of Biochemistry,Rheinisch-Westfalische Technische Hochschule ,D-52074Aachen,Germany 4 Department of Pathology,University of Iowa ,,42

Huazhong University of Science and Technology Wuhan

InstituteofClinicalImmunology

Tongji Hospital

Department of Biochemistry

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