S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS

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S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS

Chinese Medical Sciences Journal Issue 2, Pages: 93-96(1990)

Updated：2024-04-10

- S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS
- Affiliations：
  
  1. Zhejiang Branch CAMS
  2. Hanozhou
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1990
- Accepted：
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[1]黄建,黄怀德,彭清璧,朱志建,余心如.S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS[J].Chinese Medical Sciences Journal,1990(02):93-96.

S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS[J]. Chinese medical sciences journal, 1990, (2): 93-96.
[1]黄建,黄怀德,彭清璧,朱志建,余心如.S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS[J].Chinese Medical Sciences Journal,1990(02):93-96. DOI：

S100 PROTEIN-POSITIVE DENDRITIC CELLS AND THE SIGNIFICANCE OF THEIR DENSITY IN GASTRIC PRECANCEROUS LESIONS[J]. Chinese medical sciences journal, 1990, (2): 93-96. DOI：

摘要

<正> Quantitative analysis of dendritic cells （DC’s） was carried out in tissue specimens of normalgastric mucosa （n=15）

gastric ulcer （n=19）

chronic atrophic gastritis （n=28）

and gastriccarcinoma （n=65） by ABC immunostaining with S100 protein antibody.Significant increasein DC number were observed in chronic atrophic gastritis with type Ⅲ intestinal metaplasiaand/or grade Ⅱ

Ⅲ dysplasia.The result suggests that DC’s are potentially capable opresenting neoantigens associated with malignant transformation at the precancerous stagewhen malignant morphological changes have not yet taken place.Combined with routinediagnostic methods

the serial monitoring of DC density in gastric mucosa may be usefulin the follow-up of premalignant lesions in the stomach and the diagnosis of early gastriccarcinoma.

Abstract

Quantitative analysis of dendritic cells （DC’s） was carried out in tissue specimens of normal gastric mucosa （n=15）

gastric ulcer （n=19）

chronic atrophic gastritis （n=28）

and gastric carcinoma （n=65） by ABC immunostaining with S100 protein antibody.Significant increase in DC number were observed in chronic atrophic gastritis with type Ⅲ intestinal metaplasia and/or grade Ⅱ

Ⅲ dysplasia.The result suggests that DC’s are potentially capable o presenting neoantigens associated with malignant transformation at the precancerous stage when malignant morphological changes have not yet taken place.Combined with routine diagnostic methods

the serial monitoring of DC density in gastric mucosa may be useful in the follow-up of premalignant lesions in the stomach and the diagnosis of early gastric carcinoma.

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