EFFECT OF PHORBOL ESTER ON cAMP-DEPENDENT PROTEIN KINASE ACTIVITY IN CARDIOMYOCYTES

Zhou Wenhua; Xiao Dianmo; Zheng Chaoqiang; Wang Xiaolu and Zhang Junbao

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EFFECT OF PHORBOL ESTER ON cAMP-DEPENDENT PROTEIN KINASE ACTIVITY IN CARDIOMYOCYTES

Chinese Medical Sciences Journal Issue 4, (1995)

Updated：2024-04-10

- EFFECT OF PHORBOL ESTER ON cAMP-DEPENDENT PROTEIN KINASE ACTIVITY IN CARDIOMYOCYTES
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  CLC： R363
- Published：1995
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[1]周文华,肖殿模,郑超强,王小鲁,张俊保.EFFECT　OF　PHORBOL　ESTER　ON　cAMP－DEPENDENT　PROTEIN　KINASE　ACTIVITY　IN　CARDIOMYOCYTES[J].Chinese Medical Sciences Journal,1995(04):191-194.

Zhou Wenhua, Xiao Dianmo, Zheng Chaoqiang, et al. EFFECT OF PHORBOL ESTER ON cAMP-DEPENDENT PROTEIN KINASE ACTIVITY IN CARDIOMYOCYTES[J]. Chinese medical sciences journal, 1995, (4).
[1]周文华,肖殿模,郑超强,王小鲁,张俊保.EFFECT　OF　PHORBOL　ESTER　ON　cAMP－DEPENDENT　PROTEIN　KINASE　ACTIVITY　IN　CARDIOMYOCYTES[J].Chinese Medical Sciences Journal,1995(04):191-194. DOI：

Zhou Wenhua, Xiao Dianmo, Zheng Chaoqiang, et al. EFFECT OF PHORBOL ESTER ON cAMP-DEPENDENT PROTEIN KINASE ACTIVITY IN CARDIOMYOCYTES[J]. Chinese medical sciences journal, 1995, (4). DOI：

摘要

ＥＦＦＥＣＴＯＦＰＨＯＲＢＯＬＥＳＴＥＲＯＮｃＡＭＰ－ＤＥＰＥＮＤＥＮＴＰＲＯＴＥＩＮＫＩＮＡＳＥＡＣＴＩＶＩＴＹＩＮＣＡＲＤＩＯＭＹＯＣＹＴＥＳＺｈｏｕＷｅｎｈｕａ（周文华），ＸｉａｏＤｉａｎｍｏ（肖殿模），ＺｈｅｎｇＣｈａｏｑｉａｎｇ（郑超强），...

Abstract

Cardiomyocytes isolated from neonatal rats were treated with phorboll 2-myristatel 3-acetate （PMA ） ranging from 10（-11）to 10-7 mol/L for 20 min

causing cytosol protein kinase A （PKA） activity to decrease while particulate PKA activity increase in a concentration-dependent manner. The change of PKA activity induced by PMA was abolished completely by pretreatment of polymyxin B or depletion of protein kinase C （PKC）. Type II PKA activity in particulate fraction was enhanced remarkably

while that of type I PKA was not altered when the cells were treated with 100 nmol/L PMA. The results suggested that subcellular distribution and activity of PKA in cardiomyocytes may be regulated by PKC.

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