THE AUTOCRINE REGULATORY EFFECT OF VASOACTVE INTESTINAL PEPTIDE ON THE GROWTH OF HUMAN PANCREATIC CARCINOMA CELLS

Chen Yuanfang; Chen Qian; Lu Guojun; Fan Zhenfu and Zhong Shouxian

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THE AUTOCRINE REGULATORY EFFECT OF VASOACTVE INTESTINAL PEPTIDE ON THE GROWTH OF HUMAN PANCREATIC CARCINOMA CELLS

Chinese Medical Sciences Journal Issue 4, (1994)

Updated：2024-04-10

- THE AUTOCRINE REGULATORY EFFECT OF VASOACTVE INTESTINAL PEPTIDE ON THE GROWTH OF HUMAN PANCREATIC CARCINOMA CELLS
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  CLC： R363
- Published：1994
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[1]陈元方,陈潜,陆国钧,范振符,钟守先.THE　AUTOCRINE　REGULATORY　EFFECT　OF　VASOACTVE　INTESTINAL　PEPTIDE　ON　THE　GROWTH　OF　HUMAN　PANCREATIC　CARCINOMA　CELLS[J].Chinese Medical Sciences Journal,1994(04):215-219.

Chen Yuanfang, Chen Qian, Lu Guojun, et al. THE AUTOCRINE REGULATORY EFFECT OF VASOACTVE INTESTINAL PEPTIDE ON THE GROWTH OF HUMAN PANCREATIC CARCINOMA CELLS[J]. Chinese medical sciences journal, 1994, (4).
[1]陈元方,陈潜,陆国钧,范振符,钟守先.THE　AUTOCRINE　REGULATORY　EFFECT　OF　VASOACTVE　INTESTINAL　PEPTIDE　ON　THE　GROWTH　OF　HUMAN　PANCREATIC　CARCINOMA　CELLS[J].Chinese Medical Sciences Journal,1994(04):215-219. DOI：

Chen Yuanfang, Chen Qian, Lu Guojun, et al. THE AUTOCRINE REGULATORY EFFECT OF VASOACTVE INTESTINAL PEPTIDE ON THE GROWTH OF HUMAN PANCREATIC CARCINOMA CELLS[J]. Chinese medical sciences journal, 1994, (4). DOI：

摘要

ＴＨＥＡＵＴＯＣＲＩＮＥＲＥＧＵＬＡＴＯＲＹＥＦＦＥＣＴＯＦＶＡＳＯＡＣＴＶＥＩＮＴＥＳＴＩＮＡＬＰＥＰＴＩＤＥＯＮＴＨＥＧＲＯＷＴＨＯＦＨＵＭＡＮＰＡＮＣＲＥＡＴＩＣＣＡＲＣＩＮＯＭＡＣＥＬＬＳ￥ＣｈｅｎＹｕａｎｆａｎｇ陈元方，ＣｈｅｎＱｉａｎ陈潜...

Abstract

In the present study

the effects of VIP on the growth of two human pancreatic carcinoma cell lines PU-PAN-l and PANC-I were determined using tritiated thymidine incorporation. VIP receptors. intracellular cAMP and polyamines were investigated. The results indicated that VIP at a concentration of 10-8 mol/L to 10-7 mol/L can significantly stimulate the growth of PU-PAN-I cells but not PANC-1 cells. This effect is dose-dependent and abolished by VIP receptor antagonist

[4-C1-Phe6 . Leu17] VIP

suggesting VIP receptors in PU-PAN-I cells may mediate this effect. VIP can markedly elevate the levels of intracellular cAMP and polyamines in PU-PAN-I cells.indicating that the growth-promoting effect stimulated by VIP may be via a rapid increase in the biosyntheses of cAMP and polyamines. In addition

the VIP-antibody inhibited the growth of PU-PAN-I cells in serum-free culture mediurn. The results above suggested that VIP has an autocrine regulatory effect on this pancreatic carcinoma cell line （PU-PAN-1）.

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