STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES

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STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES

Chinese Medical Sciences Journal Issue 1, Pages: 43-46(1990)

Updated：2024-04-10

- STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES
- Affiliations：
  
  1. Cancer Institute CAMS
  2. ,China
  3. Institute of Radiation Medicine
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：1990
- Accepted：
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[1]李申德,刘炳辰,许德新.STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES[J].Chinese Medical Sciences Journal,1990(01):43-46.

STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES[J]. Chinese medical sciences journal, 1990, (1): 43-46.
[1]李申德,刘炳辰,许德新.STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES[J].Chinese Medical Sciences Journal,1990(01):43-46. DOI：

STUDIES ON THE RELATIONSHIP BETWEEN CHROMOSOME No15 AND THE BIOLOGICAL CHARACTERISTICS OF MALIGNANT TRANSFORMED SYRIAN HAMSTER FIBROBLAST CELL LINES[J]. Chinese medical sciences journal, 1990, (1): 43-46. DOI：

摘要

<正> During the course of malignant transformation of mammalian cells in vitro

a regular varia-tion in chromosome number and structure is usually found.In order to elucidate the rela-tionship between chromosomal changes and maligannt expression

we isolated fire clonesfrom a malignant transformed Syrian hamster fibroblast cell line and analyzed their biologicalcharacteristics

as well as chromosomal changes.A positive correlation betweetn chromosomeNo 15 monosomy and the transformed and malignant phenotype was observed.We suggestthat a suppression gene may be located on chromosome No 15

and its deletion or the lossof the chromosome may result in expression of the malignant phenotype.

Abstract

During the course of malignant transformation of mammalian cells in vitro

a regular varia- tion in chromosome number and structure is usually found.In order to elucidate the rela- tionship between chromosomal changes and maligannt expression

we isolated fire clones from a malignant transformed Syrian hamster fibroblast cell line and analyzed their biological characteristics

as well as chromosomal changes.A positive correlation betweetn chromosome No 15 monosomy and the transformed and malignant phenotype was observed.We suggest that a suppression gene may be located on chromosome No 15

and its deletion or the loss of the chromosome may result in expression of the malignant phenotype.

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