ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION
Chinese Medical Sciences JournalIssue 4, (1994)
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ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION
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CLC:R363
Published:1994
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[1]牛苏毅,张洁,黄宇光.ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION[J].Chinese Medical Sciences Journal,1994(04):233-236.
Niu Suyi, Zhang Jie, Huang Yuguang and T.H.Stanley. ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION[J]. Chinese medical sciences journal, 1994, (4).
[1]牛苏毅,张洁,黄宇光.ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION[J].Chinese Medical Sciences Journal,1994(04):233-236.DOI:
Niu Suyi, Zhang Jie, Huang Yuguang and T.H.Stanley. ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION[J]. Chinese medical sciences journal, 1994, (4).DOI:
ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION
This study explores a novel noninvasive method for monitoring blood alfentanil concentrations using a dog model. Alfentanil which "back"
permeated across the oral mucosa from the systemic circulation was collected from the oral mucosal surface and quantitated. The levels of the "back" permeated alfentanil were found to closely reflect real time serum alfentanil concentrations. With further work
this finding may lead to a novel noninvasive method for monitoring real time serum alfentanil concentrations in its clinical applications.