EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION

Zhu Kanger and Kerry Atkinson

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EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION

Chinese Medical Sciences Journal Issue 2, (1994)

Updated：2024-04-10

- EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION
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  CLC： R363
- Published：1994
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[1]朱康儿.EFFECTS　OF　INTERLEUKIN－4　ON　GRANULOCYTE－MACROPHAGE－COLONY　FORMATION　FROM　MURINE　BONE　MARROW　CELLS　AND　HEMATOPOIETIC　RECONSTIT[J].Chinese Medical Sciences Journal,1994(02):125-128.

Zhu Kanger and Kerry Atkinson. EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION[J]. Chinese medical sciences journal, 1994, (2).
[1]朱康儿.EFFECTS　OF　INTERLEUKIN－4　ON　GRANULOCYTE－MACROPHAGE－COLONY　FORMATION　FROM　MURINE　BONE　MARROW　CELLS　AND　HEMATOPOIETIC　RECONSTIT[J].Chinese Medical Sciences Journal,1994(02):125-128. DOI：

Zhu Kanger and Kerry Atkinson. EFFECTS OF INTERLEUKIN-4 ON GRANULOCYTE-MACROPHAGE-COLONY FORMATION FROM MURINE BONE MARROW CELLS AND HEMATOPOIETIC RECONSTITUTION FOLLOWING MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION[J]. Chinese medical sciences journal, 1994, (2). DOI：

摘要

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Abstract

We investigated the effects of mouse recombinant IL-4 on hematopoiesis in vitro and in vivo. IL-4 alone was found to be incapable of stimulating colony formation

but it inhibited both IL-3-and GM-CSF-induced colony formation by murine hematopoietic progenitor cells. In contrast

colony formation induced by G-CSF was enhanced in the presence of IL-4. We also studied the influence of IL-4 on hematopoietic reconstiution after allogeneic bone marrow transplantation in a murine medel

and found that IL-4 had significant inhibitory effects on neutrophil recovery and that neutrophil recovery accelerated by IL-3 and G-CSF was significantly suppressed by IL-4. The combination of IL-4 and GM-SF caused a significant decrease in the absolute number of neutrophils.

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