Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats

Cai Cui; Xu Changqing; Jin Hualiang; Li Bei

doi:10.24920/003470

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Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats

Chinese Medical Sciences Journal Vol. 33, Issue 4, Pages: 260-266(2018)

Original Article | Updated：2024-04-10

- Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats
- Affiliations：
  
  1 Department of Geriatrics, Hangzhou Red Cross Hospital, Hangzhou 310003, China
  2 Department of Respiratory, the Affiliated Hospital of Hangzhou Normal University,Hangzhou 330015, China
  3 Department of Respiratory, Hangzhou 310006, China
  4 Department of Geriatrics,Hangzhou First People’s Hospital, Hangzhou 310006, China;
- Author bio：
  
  * Tel: 86-0571-56109766; E-mail:caicui2003@aliyun.com
- Funds：
- DOI：10.24920/003470
  CLC：
- Received：09 March 2018，
  
  Accepted：2018-8-27，
  
  Published Online：07 January 2018，
  
  Published：07 January 2018
- Accepted：
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Cai Cui, Xu Changqing, Jin Hualiang, et al. Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats[J]. Chinese medical sciences journal, 2018, 33(4): 260-266.
DOI：

Cai Cui, Xu Changqing, Jin Hualiang, et al. Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats[J]. Chinese medical sciences journal, 2018, 33(4): 260-266. DOI： 10.24920/003470.

摘要

目的

老年慢性阻塞性肺疾病（Chronic obstructive pulmonary disease

COPD)患者常常合并抑郁状态

但目前对于老年人COPD伴抑郁的基础研究较少。本文探讨COPD伴抑郁对老年大鼠空间学习记忆能力的影响

将COPD、抑郁与衰老联系起来

以进一步了解老年COPD伴抑郁患者的疾病特点。

方法

将SD大鼠分为5组

分别为成年组、老年对照组、老年COPD组、老年抑郁组及老年COPD伴抑郁组。利用烟熏结合慢性轻度不可预见性应激（chronic unpredictable mild stress

CUMS)并孤养建立老年COPD伴抑郁大鼠模型。通过Morris水迷宫 (Morris water maze

MWM)试验检测大鼠的空间学习记忆能力

用黄嘌呤氧化酶法（Xanthinoxidase method）和硫代巴比妥酸反应法(TBAR)分别测定大鼠血清及海马组织中超氧化物歧化酶（SOD）的活性和丙二醛（MDA）的含量。比较各实验组与对照组各观测指标之间的差异。

结果

肺组织学、肺功能检测、敞箱实验及糖水消耗实验证实烟熏结合CUMS并孤养方法成功建立老年COPD伴抑郁大鼠模型。与老年对照组相比

老年COPD伴抑郁大鼠组在Morris水迷宫实验中到达平台的时间明显延长（LSD-

= -10.116

=0.000）

运动距离明显增加（LSD-

= -6.448

=0.000）;同时

老年COPD伴抑郁模型组中大鼠海马和血清中SOD的活性明显减少（LSD-

=2.629

=0.014; LSD-

= 2.215

=0.044)

而MDA的含量显著增加（(LSD

-t

= -2.140

=0.042; LSD

-t

=-2.070

=0.049）。

结论

慢性阻塞性肺疾病伴抑郁的老年大鼠空间学习记忆能力下降

其作用机制可能与氧化应激失衡有关。这一发现可能为临床老年COPD伴抑郁患者的治疗提供新的思路。

Abstract

Objective

To investigate the combined effects of chronic obstructive pulmonary disease (COPD) and depression on spatial memory in old rats

aiming to better understand the comorbidity of the two diseases in geriatric patients.

Methods

The SD rats were assigned into five groups: adult control group (

=6)

elderly control group (

=6)

elderly COPD group (

=6)

elderly depression group (

=6) and elderly COPD with depression group (

=6). Smoking and chronic unpredictable mild stress (CUMS) with solitary support were used to induce COPD model

depression model

respectively

and the both were applied for the comorbidity model. Learning and memory deficits were assessed by Morris water maze (MWM) test. The activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum and hippocampus tissue were determined by Xanthinoxidase method and Thiobarbituric acid reaction (TBAR) method

respectively.

Results

The results of pulmonary histology

lung function

open-field test and sucrose consumption demonstrated the comorbidity models of COPD and depression in elderly rats were successfully established using smoking and CUMS with solitary support. Compared with the elderly control group

the group of COPD with depression had obviously longer time of latency and longer travel distance to reach the platform in MWM test (LSD-

=-10.116

=0.000; LSD-

=-6.448

=0.000). The SOD activity in serum and hippocampus decreased significantly (LSD-

=2.629

=0.014; LSD-

=2.215

=0.044) and the MDA content in serum and hippocampus increased significantly (LSD-

=-2.140

=0.042; LSD-

=-2.070

=0.049) in elderly COPD with depression group.

Conclusions

COPD in comorbidity of depression could induce spatial memory deficit in old rats. The mechanisms might be related to the overloaded and free radical metabolic imbalance. These results suggest a potential therapeutic target for comorbidity of COPD and depression in geriatric patients.

关键词

Keywords

references

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