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Association between
GSTT 1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis- Affiliations：
1. 1 Sixth Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
2. 2 Department of Rheumatology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
3. 3 China Medical University, Shenyang 110013, China
- Author bio：
*E-mail: liubl@sj-hospital.org
- Funds：
DOI：10.24920/003490
CLC：Received：20 December 2018，
Published Online：18 April 2018，
Published：26 August 2019
- Accepted：
Scan QR Code
Cui Junpeng, Lin Meiyi, Liu Zhenghao, et al. Association between
GSTT 1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis[J]. Chinese medical sciences journal, 2019, 34(3): 205-210.Cui Junpeng, Lin Meiyi, Liu Zhenghao, et al. Association between
GSTT 1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis[J]. Chinese medical sciences journal, 2019, 34(3): 205-210. DOI： 10.24920/003490.
摘要
目的
探讨
GSTT
1纯合缺失与胰腺癌易感性的关系。
方法
检索PubMed database
CNKI
EMBASE数据库（发表日期截至2018年4月18日）中评价
GSTT
1基因纯合子缺失与胰腺癌关系的研究。采用RevMan5.3和Stata12.0软件分析胰腺癌患者和健康对照发生
GSTT
1基因纯合子缺失的频率
并计算
OR
值和95％置信区间（95%
CI
）。
结果
共有9篇文献纳入此项Meta分析。共包括5952例受试者
其中胰腺癌患者2387例
健康对照3565例。与对照组相比
胰腺癌患者发生
GSTT
1纯合子缺失的频率更高（33.4%比38.7%
OR
=1.26
95%
CI
=1.01-1.58
P
=0.04）。
结论
GSTT
1纯合性缺失个体可能具有更高的胰腺癌易感性。
Abstract
Objective
To clarify the possible association of
GSTT
1 homozygous deletion with the susceptibility to pancreatic cancer.
Methods
We searched PubMed database
Chinese Journal Full Text Database (CNKI)
and EMBASE to find the eligible studies published up to April 18
2018 for evaluating the relationship between
GSTT
1 homozygous deletion and pancreatic cancer. The frequency of null genotype for
GSTT
1 between the pancreatic cancer group and the healthy control group was compared with
Chi
-
square
test
and odds ratios (
OR
s) value and 95% confidence interval (95%
CI
) were calculated.
Results
A total of 9 studies met the inclusion criteria
and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis. Compared with the control group
frequency of null genotype for
GSTT
1 in the pancreatic cancer group was higher (33.4%
vs
. 38.7%
OR
= 1.26
95%
CI
= 1.01-1.58
P
= 0.04).
Conclusion
GSTT
1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.
关键词
Keywords
references
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