Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma

Wang Yingwei; Zhang Xinghua; Wang Botao; Wang Ye; Liu Mengqi; Wang Haiyi; Ye Huiyi; 陈志晔

doi:10.24920/003531

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Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma

Chinese Medical Sciences Journal Vol. 34, Issue 1, Pages: 1-9(2019)

Original Articles | Updated：2024-04-10

- Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma
- Affiliations：
  
  1. Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, China
  2. Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China
- Author bio：
  
  Huiyi Ye Tel: 86-13701100368, E-mail: 13701100368@163.com
  * Zhiye Chen Tel: 86-898-37330852, E-mail: yyqf@hotmail.com;
- Funds：
- DOI：10.24920/003531
  CLC：
- Received：18 October 2018，
  
  Revised：22 February 2019，
  
  Published Online：30 March 2019，
  
  Published：30 March 2019
- Accepted：
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Wang Yingwei, Zhang Xinghua, Wang Botao, et al. Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma[J]. Chinese medical sciences journal, 2019, 34(1): 1-9.
DOI：

Wang Yingwei, Zhang Xinghua, Wang Botao, et al. Value of Texture Analysis of Intravoxel Incoherent Motion Parameters in Differential Diagnosis of Pancreatic Neuroendocrine Tumor and Pancreatic Adenocarcinoma[J]. Chinese medical sciences journal, 2019, 34(1): 1-9. DOI： 10.24920/003531.

摘要

目的

评价体素内不相干运动成像(intravoxel incoherent motion，IVIM)参数的纹理特征在胰腺神经内分泌肿瘤和胰腺癌鉴别诊断上的价值。

方法

18例胰腺神经内分泌肿瘤患者和32例胰腺癌患者纳入此项回归性研究。所有患者术前均接受了10个b值(0-800 s/mm

)的扩散加权成像(diffusion-weighted imaging，DWI)检查，所获得图像数据应用IVIM模型进行分析，获得灰度编码的灌注分数(perfusion fraction，f)、快池扩散(fast component of diffusion，D

fast

)和慢池扩散(slow component of diffusion，D

slow

)参数图。在各组参数图上测量肿瘤最大截面的参数均值和纹理特征(包括角二阶矩，逆差距、自相关、对比度和熵)。采用独立样本t检验及Mann-Whitney U检验比较两组肿瘤间IVIM参数均值和纹理特征的差异，同时进行二元Logistic回归分析法建立回归模型，并进行受试者工作特征曲线分析评价诊断效能。

结果

胰腺神经内分泌肿瘤组的参数f值显著高于胰腺癌组(27.0% 比19.0%

= 0.001)，而参数D

fast

值和D

slow

值在两组肿瘤间的差异不具有统计学意义。各IVIM参数的所有纹理特征在两组肿瘤间的差异具有统计学意义(

= 0.000~0.043)。二元Logisic回归分析提示参数Dfast的纹理特征角二阶矩和参数D

slow

的纹理特征自相关可以作为鉴别两者肿瘤的独立变量。受试者工作特征曲线分析显示IVIM参数的多个纹理特征鉴别胰腺神经内分泌肿瘤和胰腺癌的诊断效能要优于参数的均值(曲线下面积0.849~0.899比0.526~0.776)。进入Logistic回归模型的纹理特征组合(参数D

fast

的角二阶矩和参数D

slow

的自相关)鉴别胰腺神经内分泌中和胰腺癌的诊断效能最高(曲线下面积0.934，切值0.378，敏感性0.889，特异性0.854)。

结论

IVIM参数的纹理特征分析可以作为一种有效的胰腺神经内分泌肿瘤与胰腺癌的鉴别诊断工具。

Abstract

Objective

To evaluate the value of texture features derived from intravoxel incoherent motion (IVIM) parameters for differentiating pancreatic neuroendocrine tumor (pNET) from pancreatic adenocarcinoma (PAC).

Methods

Eighteen patients with pNET and 32 patients with PAC were retrospectively enrolled in this study. All patients underwent diffusion-weighted imaging with 10

values used (from 0 to 800 s/mm

). Based on IVIM model

perfusion-related parameters including perfusion fraction (

)

fast component of diffusion (D

fast

) and true diffusion parameter slow component of diffusion (D

slow

) were calculated on a voxel-by-voxel basis and reorganized into gray-encoded parametric maps. The mean value of each IVIM parameter and texture features [Angular Second Moment (ASM)

Inverse Difference Moment (IDM)

Correlation

Contrast and Entropy]

values of IVIM parameters were measured. Independent sample

-test or Mann-Whitney

test were performed for the between-group comparison of quantitative data. Regression model was established by using binary logistic regression analysis

and receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic efficiency.

Results

The mean

value of the pNET group were significantly higher than that of the PAC group (27.0%

. 19.0%

= 0.001)

while the mean values of D

fast

and D

slow

showed no significant differences between the two groups. All texture features (ASM

IDM

Correlation

Contrast and Entropy) of each IVIM parameter showed significant differences between the pNET and PAC groups (

=0.000-0.043). Binary logistic regression analysis showed that texture ASM of D

fast

and texture Correlation of D

slow

were considered as the specific imaging variables for the differential diagnosis of pNET and PAC. ROC analysis revealed that multiple texture features presented better diagnostic performance than IVIM parameters (AUC 0.849-0.899

. 0.526-0.776)

and texture ASM of D

fast

combined with Correlation of D

slow

in the model of logistic regression had largest area under ROC curve for distinguishing pNET from PAC (AUC 0.934

cutoff 0.378

sensitivity 0.889

specificity 0.854).

Conclusion

Texture analysis of IVIM parameters could be an effective and noninvasive tool to differentiate pNET from PAC.

关键词

Keywords

references

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