Postoperative Complications and Survival Analysis of Surgical Resection for Hilar Cholangiocarcinoma: A Retrospective Study of Fifty-Nine Consecutive Patients

Zhu Weihua; Xie Wenyong; Zhang Zhedong; Li Shu; Zhang Dafang; Liu Yijun; Zhu Jiye; Leng Xisheng

doi:10.24920/003565

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Postoperative Complications and Survival Analysis of Surgical Resection for Hilar Cholangiocarcinoma: A Retrospective Study of Fifty-Nine Consecutive Patients

Chinese Medical Sciences Journal Vol. 35, Issue 2, Pages: 157-169(2020)

Original Article | Updated：2024-04-10

- Postoperative Complications and Survival Analysis of Surgical Resection for Hilar Cholangiocarcinoma: A Retrospective Study of Fifty-Nine Consecutive Patients
- Affiliations：
  
  Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100044, China
- Author bio：
  
  *,Tel: 86-10-88326702; E-mail: lishu@medmail.com.cn.
- Funds：
- DOI：10.24920/003565
  CLC：
- Received：25 January 2019，
  
  Accepted：2019-12-23，
  
  Published Online：13 June 2020，
  
  Published：13 June 2020
- Accepted：
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Zhu Weihua, Xie Wenyong, Zhang Zhedong, et al. Postoperative Complications and Survival Analysis of Surgical Resection for Hilar Cholangiocarcinoma: A Retrospective Study of Fifty-Nine Consecutive Patients[J]. Chinese medical sciences journal, 2020, 35(2): 157-169.
DOI：

Zhu Weihua, Xie Wenyong, Zhang Zhedong, et al. Postoperative Complications and Survival Analysis of Surgical Resection for Hilar Cholangiocarcinoma: A Retrospective Study of Fifty-Nine Consecutive Patients[J]. Chinese medical sciences journal, 2020, 35(2): 157-169. DOI： 10.24920/003565.

摘要

Abstract

Objective Hilar cholangiocarcinoma (HC) is invariably fatal without surgical resection. The primary aim of the current study was to determine the safety of variable surgical resections for patient with HC and their survival after surgical resection. In addition

prognostic factor for the overall survival was also evaluated. Methods The study included 59 consecutive patients who were newly diagnosed with HC and underwent surgical resections with curative intend between February 2009 and February 2017. Patients were followed up at 3-6 months intervals after hospital discharge. Postoperative complications and overall survival were determined. Associations of clinicopathologic and surgeon-related factors with overall survival were evaluated through univariate analysis and Cox regression analysis. Results Of patients with Bismuth and Corlette (B

C) type Ⅲ (

=19) and Ⅳ (

=25) HC lesions

33 (55.9%) were treated with hilar resection combined with major liver resection (MLR)

while the other 11 patients with type Ⅲ and Ⅳ

and those with type Ⅰ (

=8) and Ⅱ (

=7) HC lesions were treated with hilar resection. The overall surgical mortality was 5.1% and surgical morbidity was 35.6%. There was no statistical difference in the mortality between MLR group and hilar resection group (6.1%

vs.

3.8%;

=0.703

=0.145). The median follow-up period was 18 months (range

1-94 months). The 1-

5-year survival rate was 59.3%

36.5%

and 17.7%

respectively. The overall survival after resections was 18 months. In HC patients with B

C type Ⅲ and Ⅳ lesions

the median survival was 23 months for hilar resection with MLR and 8 months for hilar resection alone; the 1-

5-year cumulative survival rate was 63.9%

23.3%

and 15.5%

respectively for hilar resection with MLR

and 11.1%

and 0

respectively for hilar resection alone

with significant differene observed (

9.902; 95%

2.636-19.571

=0.001). Four factors were independently associated with overall survival: preoperative serum Ca19-9 (

7.039; 95%

2.803-17.678

0.001)

histopathologic grade (

4.964; 95%

1.046-23.552

=0.044)

surgical margins (

=0.031)

and AJCC staging (

=0.015). Conclusions R0 resection is efficacious in surgical treatment of HC. MLR in combination with caudate lobe resection may increase the chance of R0 resection and improve survival of HC patients with B

C type Ⅲ and Ⅳ lesions. Preoperatively prepared for biliary drainage may ensure the safety of MLR in most HC patients. Novel adjuvant therapies are needed to improve the survival of HC patients with poor prognostic factors.

关键词

Keywords

references

Altemeier WA , Gall EA , Zinninger MM , et al . Sclerosing carcinoma of the major intrahepatic bile ducts . AMA Arch Surg 1957 ; 75 ( 3 ): 450 - 60 . doi: 10.1001/archsurg.1957.01280150140015 https://dx.doi.org/archsurg.1957.01280150140015 . DOI: 10.1001/archsurg.1957.01280150140015 http://doi.org/10.1001/archsurg.1957.01280150140015 https://www.ncbi.nlm.nih.gov/pubmed/13457619 https://www.ncbi.nlm.nih.gov/pubmed/13457619

Klatskin G . Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis: an unusual tumor with distinctive clinical and pathological features . Am J Med 1965 ; 38 ( 2 ): 241 - 56 . doi: 10.1016/0002-9343(65)90178-6 https://dx.doi.org/0002-9343(65)90178-6 . DOI: 10.1016/0002-9343(65)90178-6 http://doi.org/10.1016/0002-9343(65)90178-6 https://linkinghub.elsevier.com/retrieve/pii/0002934365901786 https://linkinghub.elsevier.com/retrieve/pii/0002934365901786

Bismuth H , Nakache R , Diamond T . Management strategies in resection for hilar cholangiocarcinoma . Ann Surg 1992 ; 215 ( 1 ): 31 - 8 . doi: 10.1097/00000658-199201000-00005 https://dx.doi.org/00000658-199201000-00005 . DOI: 10.1097/00000658-199201000-00005 http://doi.org/10.1097/00000658-199201000-00005 https://www.ncbi.nlm.nih.gov/pubmed/1309988 https://www.ncbi.nlm.nih.gov/pubmed/1309988

Hemming AW , Reed AI , Fujita S , et al . Surgical management of hilar cholangiocarcinoma . Ann Surg 2005 ; 241 ( 5 ): 693 - 9 . doi: 10.1097/01.sla.0000160701.38945.82 https://dx.doi.org/01.sla.0000160701.38945.82 . DOI: 10.1097/01.sla.0000160701.38945.82 http://doi.org/10.1097/01.sla.0000160701.38945.82 https://www.ncbi.nlm.nih.gov/pubmed/15849505 https://www.ncbi.nlm.nih.gov/pubmed/15849505

Sano T , Shimada K , Sakamoto Y , et al . One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality . Ann Surg 2006 ; 244 ( 2 ): 240 - 7 . doi: 10.1097/01.sla.0000217605.66519.38 https://dx.doi.org/01.sla.0000217605.66519.38 . DOI: 10.1097/01.sla.0000217605.66519.38 http://doi.org/10.1097/01.sla.0000217605.66519.38 https://www.ncbi.nlm.nih.gov/pubmed/16858186 https://www.ncbi.nlm.nih.gov/pubmed/16858186

Miyazaki M , Ito H , Nakagawa K , et al . Segments Ⅰ and Ⅳ resection as a new approach for hepatic hilar cholangiocarcinoma . Am J Surg 1998 ; 175 ( 3 ): 229 - 31 . doi: 10.1016/s0002-9610(97)00295-x https://dx.doi.org/s0002-9610(97)00295-x . DOI: 10.1016/s0002-9610(97)00295-x http://doi.org/10.1016/s0002-9610(97)00295-x https://www.ncbi.nlm.nih.gov/pubmed/9560126 https://www.ncbi.nlm.nih.gov/pubmed/9560126

Gerhards MF , van Gulik TM , de Wit LT , et al . Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma: a single center experience . Surgery 2000 ; 127 ( 4 ): 395 - 404 . doi: 10.1067/msy.2000.104250 https://dx.doi.org/msy.2000.104250 . DOI: 10.1067/msy.2000.104250 http://doi.org/10.1067/msy.2000.104250 https://www.ncbi.nlm.nih.gov/pubmed/10776430 https://www.ncbi.nlm.nih.gov/pubmed/10776430

Tirelli G , Gatto A , Boscolo NF , et al . Prognosis of oral cancer: a comparison of the staging systems given in the 7th and 8th editions of the American Joint Committee on Cancer Staging Manual . Bri J Oral Maxillofac Surg 2018 ; 56 ( 1 ): 8 - 13 . doi: 10.1016/j.bjoms.2017.11.009 https://dx.doi.org/j.bjoms.2017.11.009 .

Gaspersz M , Buettner S , Van Vugt J , et al . Evaluation of the New American Joint Committee on cancer staging manual 8th edition for perihilar cholangiocarcinoma . HPB 2018 ; 20 ( 5 ): S182 - 3 . doi: 10.1016/j.hpb.2018.06.023 https://dx.doi.org/j.hpb.2018.06.023 .

Bas GK , Jimme KW , Peter JA , et al . American Joint Committee on Cancer staging for resected perihilar cholangiocarcinoma: a comparison of the 6th and 7th editions . HPB (Oxford) 2014 ; 16 ( 12 ): 1074 - 82 . doi: 10.1111/hpb.12320 https://dx.doi.org/hpb.12320 . DOI: 10.1111/hpb.12320 http://doi.org/10.1111/hpb.12320 https://linkinghub.elsevier.com/retrieve/pii/S1365182X15315161 https://linkinghub.elsevier.com/retrieve/pii/S1365182X15315161

Wente MN , Bassi C , Dervenis C . Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS) . Surgery 2007 ; 142 ( 5 ): 761 - 8 . doi: 10.1016/j.surg.2007.05.005 https://dx.doi.org/j.surg.2007.05.005 . DOI: 10.1016/j.surg.2007.05.005 http://doi.org/10.1016/j.surg.2007.05.005 https://www.ncbi.nlm.nih.gov/pubmed/17981197 https://www.ncbi.nlm.nih.gov/pubmed/17981197

Vincent JL . Sepsis definitions . Lancet Infect Dis 2002 ; 2 ( 3 ): 135 . doi: 10.1016/s1473-3099(02)00232-3 https://dx.doi.org/s1473-3099(02)00232-3 . DOI: 10.1016/s1473-3099(02)00232-3 http://doi.org/10.1016/s1473-3099(02)00232-3 https://www.ncbi.nlm.nih.gov/pubmed/11944181 https://www.ncbi.nlm.nih.gov/pubmed/11944181

Nikpour AM , Knebel RJ , Cheng D , et al . Diagnosis and management of postoperative biliary leaks . Semin Intervent Radiol 2016 ; 33 ( 4 ): 307 - 12 . doi: 10.1055/s-0036-1592324 https://dx.doi.org/s-0036-1592324 . DOI: 10.1055/s-0036-1592324 http://doi.org/10.1055/s-0036-1592324 https://www.ncbi.nlm.nih.gov/pubmed/27904250 https://www.ncbi.nlm.nih.gov/pubmed/27904250

Koch M , Garden OJ , Padbury R , et al . Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery . Surgery 2011 ; 149 ( 5 ): 680 - 8 . doi: 10.1016/j.surg.2010.12.002 https://dx.doi.org/j.surg.2010.12.002 . DOI: 10.1016/j.surg.2010.12.002 http://doi.org/10.1016/j.surg.2010.12.002 http://dx.doi.org/10.1016/j.surg.2010.12.002 http://dx.doi.org/10.1016/j.surg.2010.12.002

Blanc T , Cortes A , Goere D , et al . Hemorrhage after pancreaticoduodenectomy: when is surgery still indicated? Am J Surg 2007 ; 194 ( 1 ): 3 - 9 . doi: 10.1016/j.amjsurg.2006.08.088 https://dx.doi.org/j.amjsurg.2006.08.088 . DOI: 10.1016/j.amjsurg.2006.08.088 http://doi.org/10.1016/j.amjsurg.2006.08.088 https://www.ncbi.nlm.nih.gov/pubmed/17560900 https://www.ncbi.nlm.nih.gov/pubmed/17560900

Wente MN , Veit JA , Bassi C , et al . Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition . Surgery 2007 ; 142 ( 1 ): 20 - 5 . doi: 10.1016/j.surg.2007.02.001 https://dx.doi.org/j.surg.2007.02.001 . DOI: 10.1016/j.surg.2007.02.001 http://doi.org/10.1016/j.surg.2007.02.001 https://www.ncbi.nlm.nih.gov/pubmed/17629996 https://www.ncbi.nlm.nih.gov/pubmed/17629996

Rahbari NN , Garden OJ , Padbury R , et al . Post-hepatectomy haemorrhage: a definition and grading by the International Study Group of Liver Surgery (ISGLS) . HPB (Oxford) 2011 ; 13 ( 8 ): 528 - 35 . doi: 10.1111/j.1477-2574.2011.00319.x https://dx.doi.org/j.1477-2574.2011.00319.x . DOI: 10.1111/j.1477-2574.2011.00319.x http://doi.org/10.1111/j.1477-2574.2011.00319.x https://linkinghub.elsevier.com/retrieve/pii/S1365182X1530472X https://linkinghub.elsevier.com/retrieve/pii/S1365182X1530472X

Rahbari NN , Garden OJ , Padbury R , et al . Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS) . Surgery 2011 ; 149 ( 5 ): 713 - 24 . doi: 10.1016/j.surg.2010.10.001 https://dx.doi.org/j.surg.2010.10.001 . DOI: 10.1016/j.surg.2010.10.001 http://doi.org/10.1016/j.surg.2010.10.001 http://dx.doi.org/10.1016/j.surg.2010.10.001 http://dx.doi.org/10.1016/j.surg.2010.10.001

Kawasaki S , Imamura H , Kobayashi A , et al . Results of surgical resection for patients with hilar bile duct cancer: application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization . Ann Surg 2003 ; 238 ( 1 ): 84 - 92 . doi: 10.1097/01.sla.0000074984.83031.02 https://dx.doi.org/01.sla.0000074984.83031.02 . DOI: 10.1097/01.SLA.0000074984.83031.02 http://doi.org/10.1097/01.SLA.0000074984.83031.02 https://www.ncbi.nlm.nih.gov/pubmed/12832969 https://www.ncbi.nlm.nih.gov/pubmed/12832969

Dinant S , Gerhards MF , Rauws EA , et al . Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumor) . Ann Surg Oncol 2006 ; 13 ( 6 ): 872 - 80 . doi: 10.1245/aso.2006.05.053 https://dx.doi.org/aso.2006.05.053 . DOI: 10.1245/ASO.2006.05.053 http://doi.org/10.1245/ASO.2006.05.053 http://www.springerlink.com/content/55024j096n8j38m8/ http://www.springerlink.com/content/55024j096n8j38m8/

Seyama Y , Kubota K , Sano K , et al . Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate . Ann Surg 2003 ; 238 ( 1 ): 73 - 83 . doi: 10.1097/01.sla.0000074960.55004.72 https://dx.doi.org/01.sla.0000074960.55004.72 . DOI: 10.1097/01.SLA.0000074960.55004.72 http://doi.org/10.1097/01.SLA.0000074960.55004.72 https://www.ncbi.nlm.nih.gov/pubmed/12832968 https://www.ncbi.nlm.nih.gov/pubmed/12832968

Nakeeb A , Pitt HA , Sohn TA , et al . Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors . Ann Surg 1996 ; 224 ( 4 ): 463 - 75 . doi: 10.1097/00000658-199610000-00005 https://dx.doi.org/00000658-199610000-00005 . DOI: 10.1097/00000658-199610000-00005 http://doi.org/10.1097/00000658-199610000-00005 https://www.ncbi.nlm.nih.gov/pubmed/8857851 https://www.ncbi.nlm.nih.gov/pubmed/8857851

Todoroki T , Kawamoto T , Koike N , et al . Radical resection of hilarbile duct carcinoma and predictors of survival . Br J Surg 2000 ; 87 ( 3 ): 306 - 13 . doi: 10.1046/j.1365-2168.2000.01343.x https://dx.doi.org/j.1365-2168.2000.01343.x . DOI: 10.1046/j.1365-2168.2000.01343.x http://doi.org/10.1046/j.1365-2168.2000.01343.x https://www.ncbi.nlm.nih.gov/pubmed/10718799 https://www.ncbi.nlm.nih.gov/pubmed/10718799

Nimura Y , Kamiya J , Kondo S , et al . Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience . J Hepatobiliary Pancreat Surg 2000 ; 7 ( 2 ): 155 - 62 . doi: 10.1007/s005340050170 https://dx.doi.org/s005340050170 . DOI: 10.1007/s005340050170 http://doi.org/10.1007/s005340050170 https://www.ncbi.nlm.nih.gov/pubmed/10982608 https://www.ncbi.nlm.nih.gov/pubmed/10982608

Klempnauer J , Ridder GJ , von Wasielewski R , et al . Resectional surgery of hilar cholangiocarcinoma: a multivariate analysis of prognostic factors . J Clin Oncol 1997 ; 15 ( 3 ): 947 - 54 . doi: 10.1200/jco.1997.15.3.947 https://dx.doi.org/jco.1997.15.3.947 . DOI: 10.1200/JCO.1997.15.3.947 http://doi.org/10.1200/JCO.1997.15.3.947 https://www.ncbi.nlm.nih.gov/pubmed/9060532 https://www.ncbi.nlm.nih.gov/pubmed/9060532

Kondo S , Hirano S , Ambo Y , et al . Forty consecutive resections of hilar cholangiocarcinoma with no postoperative mortality and no positive ductal margins: results of a prospective study . Ann Surg 2004 ; 240 ( 1 ): 95 - 101 . doi: 10.1097/01.sla.0000129491.43855.6b https://dx.doi.org/01.sla.0000129491.43855.6b . DOI: 10.1097/01.sla.0000129491.43855.6b http://doi.org/10.1097/01.sla.0000129491.43855.6b https://www.ncbi.nlm.nih.gov/pubmed/15213624 https://www.ncbi.nlm.nih.gov/pubmed/15213624

Rea DJ , Munoz-Juarez M , Farnell MB , et al . Major hepatic resection for hilar cholangiocarcinoma: analysis of 46 patients . Arch Surg 2004 ; 139 ( 5 ): 514 - 23 . doi: 10.1001/archsurg.139.5.514 https://dx.doi.org/archsurg.139.5.514 . DOI: 10.1001/archsurg.139.5.514 http://doi.org/10.1001/archsurg.139.5.514 https://www.ncbi.nlm.nih.gov/pubmed/15136352 https://www.ncbi.nlm.nih.gov/pubmed/15136352

Kang MJ , Jang JY , Chang J , et al . Actual long-term survival outcome of 403 consecutive patients with hilar cholangiocarcinoma . World J Surg 2016 ; 40 ( 10 ): 2451 - 9 . doi: 10.1007/s00268-016-3551-9 https://dx.doi.org/s00268-016-3551-9 . DOI: 10.1007/s00268-016-3551-9 http://doi.org/10.1007/s00268-016-3551-9 https://www.ncbi.nlm.nih.gov/pubmed/27206402 https://www.ncbi.nlm.nih.gov/pubmed/27206402

MC de Jong , Marques H , Clary BM , et al . The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: a multi-institutional analysis of 305 cases . Cancer 2012 ; 118 ( 19 ): 4737 - 47 . doi: 10.1002/cncr.27492 https://dx.doi.org/cncr.27492 . DOI: 10.1002/cncr.27492 http://doi.org/10.1002/cncr.27492 https://www.ncbi.nlm.nih.gov/pubmed/22415526 https://www.ncbi.nlm.nih.gov/pubmed/22415526

Hemming AW , Mekeel K , Khanna A , et al . Portal vein resection in management of hilar cholangiocarcinoma . J Am Coll Surg 2011 ; 212 ( 4 ): 604 - 13 . doi: 10.1016/j.jamcollsurg.2010.12.028 https://dx.doi.org/j.jamcollsurg.2010.12.028 . DOI: 10.1016/j.jamcollsurg.2010.12.028 http://doi.org/10.1016/j.jamcollsurg.2010.12.028 https://www.ncbi.nlm.nih.gov/pubmed/21463797 https://www.ncbi.nlm.nih.gov/pubmed/21463797

Saxena A , Chua TC , Chu FC , et al . Improved outcomes after aggressive surgical resection of hilar cholangiocarcinoma: a critical analysis of recurrence and survival . Am J Surg 2011 ; 202 ( 3 ): 310 - 20 . doi: 10.1016/j.amjsurg.2010.08.041 https://dx.doi.org/j.amjsurg.2010.08.041 . DOI: 10.1016/j.amjsurg.2010.08.041 http://doi.org/10.1016/j.amjsurg.2010.08.041 http://dx.doi.org/10.1016/j.amjsurg.2010.08.041 http://dx.doi.org/10.1016/j.amjsurg.2010.08.041

Scurtu RR , Dindelegan G , Bintintan V , et al . Extension of hepatic resection ameliorates survival in patients with type Ⅲ a or Ⅲ b klatskin tumors despite surgical complications . Chirurgia (Bucur) 2017 ; 112 ( 3 ): 301 - 7 . doi: 10.21614/chirurgia.112.3.301 https://dx.doi.org/chirurgia.112.3.301 .

Cheng QB , Yi B , Wang JH , et al . Resection with total caudate lobectomy confers survival benefit in hilar cholangiocarcinoma of Bismuth type Ⅲ and Ⅳ . Eur J Surg Oncol 2012 ; 38 ( 12 ): 1197 - 203 . doi: 10.1016/j.ejso.2012.08.009 https://dx.doi.org/j.ejso.2012.08.009 . DOI: 10.1016/j.ejso.2012.08.009 http://doi.org/10.1016/j.ejso.2012.08.009 https://www.ncbi.nlm.nih.gov/pubmed/22992326 https://www.ncbi.nlm.nih.gov/pubmed/22992326

Xiong J , Nunes QM , Huang W , et al . Major hepatectomy in Bismuth types Ⅰ and Ⅱ hilar cholangiocarcinoma . J Surg Res 2015 ; 194 ( 1 ): 194 - 201 . doi: 10.1016/j.jss.2014.10.029 https://dx.doi.org/j.jss.2014.10.029 . DOI: 10.1016/j.jss.2014.10.029 http://doi.org/10.1016/j.jss.2014.10.029 https://www.ncbi.nlm.nih.gov/pubmed/25454973 https://www.ncbi.nlm.nih.gov/pubmed/25454973

Miyazaki M , Kimura F , Shimizu H , et al . One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types Ⅱ, Ⅲ, Ⅳ between 2001 and 2008 . J Hepatobiliary Pancreat Sci 2010 ; 17 ( 4 ): 470 - 5 . doi: 10.1007/s00534-009-0207-2 https://dx.doi.org/s00534-009-0207-2 . DOI: 10.1007/s00534-009-0207-2 http://doi.org/10.1007/s00534-009-0207-2 https://www.ncbi.nlm.nih.gov/pubmed/19936600 https://www.ncbi.nlm.nih.gov/pubmed/19936600

Abd El Wahab M , El Nakeeb A , El Hanafy E , et al . Predictors of long term survival after hepatic resection for hilar cholangiocarcinoma: A retrospective study of 5-year survivors . World J Gastrointest Surg 2016 ; 8 ( 6 ): 436 - 43 . doi: 10.4240/wjgs.v8.i6.436 https://dx.doi.org/wjgs.v8.i6.436 . DOI: 10.4240/wjgs.v8.i6.436 http://doi.org/10.4240/wjgs.v8.i6.436 https://www.ncbi.nlm.nih.gov/pubmed/27358676 https://www.ncbi.nlm.nih.gov/pubmed/27358676

Li M , Li K , Qi X , et al . Percutaneous transhepatic biliary stent implantation for obstructive jaundice of perihilar cholangiocarcinoma: a prospective study on predictors of stent patency and survival in 92 patients . J Vasc Interv Radiol 2016 ; 27 ( 7 ): 1047 - 55 . doi: 10.1016/j.jvir.2016.02.035 https://dx.doi.org/j.jvir.2016.02.035 . DOI: 10.1016/j.jvir.2016.02.035 http://doi.org/10.1016/j.jvir.2016.02.035 https://www.ncbi.nlm.nih.gov/pubmed/27241392 https://www.ncbi.nlm.nih.gov/pubmed/27241392

Juntermanns B , Radunz S , Heuer M , et al . Tumor markers as a diagnostic key for hilar cholangiocarcinoma . Eur J Med Res 2010 ; 15 ( 8 ): 357 - 61 . doi: 10.1186/2047-783x-15-8-357 https://dx.doi.org/2047-783x-15-8-357 . DOI: 10.1186/2047-783x-15-8-357 http://doi.org/10.1186/2047-783x-15-8-357 https://www.ncbi.nlm.nih.gov/pubmed/20947473 https://www.ncbi.nlm.nih.gov/pubmed/20947473

Hasegawa S , Ikai I , Fujii H , et al . Surgical resection of hilar cholangiocarcinoma: analysis of survival and postoperative complications . World J Surg 2007 ; 31 ( 6 ): 1256 - 63 . doi: 10.1007/s00268-007-9001-y https://dx.doi.org/s00268-007-9001-y . DOI: 10.1007/s00268-007-9001-y http://doi.org/10.1007/s00268-007-9001-y https://www.ncbi.nlm.nih.gov/pubmed/17453285 https://www.ncbi.nlm.nih.gov/pubmed/17453285

Yubin L , Chihua F , Zhixiang J , et al . Surgical management and prognostic factors of hilar cholangiocarcinoma: experience with 115 cases in China . Ann Surg Oncol 2008 ; 15 ( 8 ): 2113 - 9 . doi: 10.1245/s10434-008-9932-z https://dx.doi.org/s10434-008-9932-z . DOI: 10.1245/s10434-008-9932-z http://doi.org/10.1245/s10434-008-9932-z http://www.springerlink.com/content/c373063531x13jn7/ http://www.springerlink.com/content/c373063531x13jn7/

Ebata T , Nagino M , Kamiya J , et al . Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases . Ann Surg 2003 ; 238 ( 5 ): 720 - 7 . doi: 10.1097/01.sla.0000094437.68038.a3 https://dx.doi.org/01.sla.0000094437.68038.a3 . DOI: 10.1097/01.sla.0000094437.68038.a3 http://doi.org/10.1097/01.sla.0000094437.68038.a3 https://www.ncbi.nlm.nih.gov/pubmed/14578735 https://www.ncbi.nlm.nih.gov/pubmed/14578735

Kitagawa Y , Nagino M , Kamiya J , et al . Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection . Ann Surg 2001 ; 233 ( 3 ): 385 - 92 . doi: 10.1097/00000658-200103000-00013 https://dx.doi.org/00000658-200103000-00013 . DOI: 10.1097/00000658-200103000-00013 http://doi.org/10.1097/00000658-200103000-00013 https://www.ncbi.nlm.nih.gov/pubmed/11224627 https://www.ncbi.nlm.nih.gov/pubmed/11224627

Ito F , Cho CS , Rikkers LF , et al . Hilar cholangiocarcinoma: current management . Ann Surg 2009 ; 250 ( 2 ): 210 - 8 . doi: 10.1097/sla.0b013e3181afe0ab https://dx.doi.org/sla.0b013e3181afe0ab . DOI: 10.1097/SLA.0b013e3181afe0ab http://doi.org/10.1097/SLA.0b013e3181afe0ab https://www.ncbi.nlm.nih.gov/pubmed/19638920 https://www.ncbi.nlm.nih.gov/pubmed/19638920

Witzigmann H , Berr F , Ringel U , et al . Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma: palliative photodynamic therapy plus stenting is comparable to R1/R2 resection . Ann Surg 2006 ; 244 ( 2 ): 230 - 9 . doi: 10.1097/01.sla.0000217639.10331.47 https://dx.doi.org/01.sla.0000217639.10331.47 . DOI: 10.1097/01.sla.0000217639.10331.47 http://doi.org/10.1097/01.sla.0000217639.10331.47 https://www.ncbi.nlm.nih.gov/pubmed/16858185 https://www.ncbi.nlm.nih.gov/pubmed/16858185

Ito F , Agni R , Rettammel RJ , et al . Resection of hilar cholangiocarcinoma: concomitant liver resection decreases hepatic recurrence . Ann Surg 2008 ; 248 ( 2 ): 273 - 9 . doi: 10.1097/sla.0b013e31817f2bfd https://dx.doi.org/sla.0b013e31817f2bfd . DOI: 10.1097/SLA.0b013e31817f2bfd http://doi.org/10.1097/SLA.0b013e31817f2bfd https://www.ncbi.nlm.nih.gov/pubmed/18650638 https://www.ncbi.nlm.nih.gov/pubmed/18650638

Su CH , Tsay SH , Wu CC , et al . Factors influencing postoperative morbidity, mortality, and survival after resection for hilar cholangiocarcinoma . Ann Surg 1996 ; 223 ( 4 ): 384 - 94 . doi: 10.1097/00000658-199604000-00007 https://dx.doi.org/00000658-199604000-00007 . DOI: 10.1097/00000658-199604000-00007 http://doi.org/10.1097/00000658-199604000-00007 https://www.ncbi.nlm.nih.gov/pubmed/8633917 https://www.ncbi.nlm.nih.gov/pubmed/8633917

Kosuge T , Yamamoto J , Shimada K , et al . Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection . Ann Surg 1999 ; 230 ( 5 ): 663 - 71 . doi: 10.1097/00000658-199911000-00008 https://dx.doi.org/00000658-199911000-00008 . DOI: 10.1097/00000658-199911000-00008 http://doi.org/10.1097/00000658-199911000-00008 https://www.ncbi.nlm.nih.gov/pubmed/10561090 https://www.ncbi.nlm.nih.gov/pubmed/10561090

Nagino M , Kamiya J , Uesaka K , et al . Complications of hepatectomy for hilar cholangiocarcinoma . World J Surg 2001 ; 25 ( 10 ): 1277 - 83 . doi: 10.1007/s00268-001-0110-8 https://dx.doi.org/s00268-001-0110-8 . DOI: 10.1007/s00268-001-0110-8 http://doi.org/10.1007/s00268-001-0110-8 http://www.springerlink.com/content/gl4478xhbcxtew8w/ http://www.springerlink.com/content/gl4478xhbcxtew8w/

Yu FX , Ji SQ , Su LF , et al . Effectiveness and safety of preoperative percutaneous transhepatic cholangiodrainage with bile re-infusion in patients with hilar cholangiocarcinoma: a retrospective controlled study . Am J Med Sci 2013 ; 346 ( 5 ): 353 - 7 . doi: 10.1097/maj.0b013e3182755de6 https://dx.doi.org/maj.0b013e3182755de6 . WOS:000330433500002 WOS:000330433500002

Kennedy TJ , Yopp A , Qin Y , et al . Role of preoperative biliary drainage of liver remnant prior to extended liver resection for hilar cholangiocarcinoma . HPB (Oxford) 2009 ; 11 ( 5 ): 445 - 51 . doi: 10.1111/j.1477-2574.2009.00090.x https://dx.doi.org/j.1477-2574.2009.00090.x . DOI: 10.1111/j.1477-2574.2009.00090.x http://doi.org/10.1111/j.1477-2574.2009.00090.x https://linkinghub.elsevier.com/retrieve/pii/S1365182X15301830 https://linkinghub.elsevier.com/retrieve/pii/S1365182X15301830

Xiong JJ , Nunes MQ , Huang W , et al . Preoperative biliary drainage in patients with hilar cholangiocarcinoma undergoing major hepatectomy . World J Gastroenterol 2013 ; 19 ( 46 ): 8731 - 9 . doi: 10.3748/wjg.v19.i46.8731 https://dx.doi.org/wjg.v19.i46.8731 . DOI: 10.3748/wjg.v19.i46.8731 http://doi.org/10.3748/wjg.v19.i46.8731 https://www.ncbi.nlm.nih.gov/pubmed/24379593 https://www.ncbi.nlm.nih.gov/pubmed/24379593

Farges O , Regimbeau JM , Fuks D , et al . Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma . Br J Surg 2013 ; 100 ( 2 ): 274 - 83 . doi: 10.1002/bjs.8950 https://dx.doi.org/bjs.8950 . DOI: 10.1002/bjs.8950 http://doi.org/10.1002/bjs.8950 https://www.ncbi.nlm.nih.gov/pubmed/23124720 https://www.ncbi.nlm.nih.gov/pubmed/23124720

El-Hanafy E . Pre-operative biliary drainage in hilar cholangiocarcinoma, benefits and risks, single center experience . Hepatogastroenterology 2010 ; 57 ( 99-100 ): 414 - 9 . doi: 10.1136/gut.2009.183046 https://dx.doi.org/gut.2009.183046 . https://www.ncbi.nlm.nih.gov/pubmed/20698200 https://www.ncbi.nlm.nih.gov/pubmed/20698200

Gerhards MF , van Gulik TM , de Wit LT , et al . Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma—a single center experience . Surgery 2000 ; 127 ( 4 ): 395 - 404 . doi: 10.1067/msy.2000.104250 https://dx.doi.org/msy.2000.104250 . DOI: 10.1067/msy.2000.104250 http://doi.org/10.1067/msy.2000.104250 https://www.ncbi.nlm.nih.gov/pubmed/10776430 https://www.ncbi.nlm.nih.gov/pubmed/10776430

Schindl MJ , Redhead DN , Fearon KC , et al . The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection . Gut 2005 ; 54 ( 2 ): 289 - 96 . doi: 10.1136/gut.2004.046524 https://dx.doi.org/gut.2004.046524 . DOI: 10.1136/gut.2004.046524 http://doi.org/10.1136/gut.2004.046524 https://www.ncbi.nlm.nih.gov/pubmed/15647196 https://www.ncbi.nlm.nih.gov/pubmed/15647196

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