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Acute Myocardial Infarction After Tranexamic Acid: Review of Published Case Reports
- Affiliations：
1Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
2Department of Adult Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
3Department of Anesthesiology, Jingmen No. 1 People’s Hospital, Jingmen, Hubei 448000, China
- Author bio：
* E-mail: yuntaiyao@126.com
- Funds：
DOI：10.24920/003596
CLC：-
Published Online：31 March 2020，
Published：20 January 2020
- Accepted：
Scan QR Code
Yao Yuntai, Yuan Xin, Shao Ken. Acute Myocardial Infarction After Tranexamic Acid: Review of Published Case Reports[J]. Chinese medical sciences journal, 2020, 35(1): 65-70.
Yao Yuntai, Yuan Xin, Shao Ken. Acute Myocardial Infarction After Tranexamic Acid: Review of Published Case Reports[J]. Chinese medical sciences journal, 2020, 35(1): 65-70. DOI： 10.24920/003596.
摘要
目的
总结已发表的氨甲环酸（TXA）相关的急性心肌梗死（AMI）病例。
方法
我们在电子数据库中检索已发表的TXA治疗后的AMI病例
并分别提取入选病例的相关数据
包括患者AMI的临床表现、辅助检查、药物治疗史、AMI治疗结果及预后。
结果
最终检索出7篇已发表的TXA治疗后的AMI病例报道（共7例患者）
其中2篇来自美国
其余5篇分别来自印度、土耳其、英国、意大利和法国。7例患者中
年龄最轻者28岁
最长者77岁
5例为女性
2例为男性。4人接受TXA治疗系因外科出血、2例因月经出血、1例因咯血。7例患者AMI的诊断基于症状、ECG表现、心肌酶及冠状动脉造影。4例患者在确诊后接受了冠状动脉支架植入术、抗血小板及抗凝治疗等。在住院及随访期内
无死亡病例
7例均未发生其他重大的心血管事件。
结论
本文提示TXA与AMI可能相关。即便是栓塞低风险的患者
这种风险也值得重视。
Abstract
Objective
To summarize cases of acute myocardial infarction (AMI) after tranexamic acid (TXA) administration.
Methods
Electronic databases were searched to identify all case reports presenting AMI after use of TXA. Two authors independently extracted data of patients’ manifestation
examinations
medical history
treatment and outcome.
Results
Our search yielded seven case reports including seven patients. Among the seven reports
two were from USA
and the other five were from India
Turkey
UK
Italy and France
respectively. Of the seven patients aged between 28- and 77-year-old who developed AMI after TXA
five patients were female and two were male. TXA was prescribed for four patients to reduce surgical bleeding
for two patients to treat menorrhagia and for one patient to manage hemoptysis. The diagnosis of AMI was made based upon patients’ symptoms
ECG
myocardium-specific enzymes
and confirmed by coronary angiography. Coronary stents were placed in four patients
for whom anti-platelet and anti-coagulation drugs were prescribed. No death or major cardiovascular events were reported during hospitalization and follow-up.
Conclusion
These case reports suggested a possible association of TXA administration and an increased risk of AMI
even in patients with relatively low thrombotic risk.
关键词
Keywords
references
Ker K , Edwards P , Perel P , et al . Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis . BMJ 2012 ; 344 : e3054 . doi: 10.1136/bmj.e3054 10.1136/bmj.e3054 .
Fergusson DA , Hébert PC , Mazer CD , et al . A comparison of aprotinin and lysine analogues in high-risk cardiac surgery . N Engl J Med 2008 ; 358 ( 22 ): 2319 - 31 . doi: 10.1056/NEJMoa0802395 10.1056/NEJMoa0802395 .
Tengborn L , Blombäck M , Berntorp E . Tranexamic acid—an old drug still going strong and making a revival . Thromb Res 2015 ; 135 ( 2 ): 231 - 42 . doi: 10.1016/j.thromres.2014.11.012 10.1016/j.thromres.2014.11.012 .
Dai Z , Chu H , Wang S , et al . The effect of tranexamic acid to reduce blood loss and transfusion on off-pump coronary artery bypass surgery: a systematic review and cumulative meta-analysis . J Clin Anesth 2018 ; 44 : 23 - 31 . doi: 10.1016/j.jclinane.2017.10.004 10.1016/j.jclinane.2017.10.004 .
Amer KM , Rehman S , Amer K , et al . Efficacy and safety of tranexamic acid in orthopaedic fracture surgery: a meta-analysis and systematic literature review . J Orthop Trauma 2017 ; 31 ( 10 ): 520 - 5 . doi: 10.1097/BOT.0000000000000919 10.1097/BOT.0000000000000919 .
Zehtabchi S , Abdel Baki SG , Falzon L , et al . Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis . Am J Emerg Med 2014 ; 32 ( 12 ): 1503 - 9 . doi: 10.1016/j.ajem.2014.09.023 10.1016/j.ajem.2014.09.023 .
CRASH-2 trial collaborators , Shakur H , Roberts I , et al . Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial . Lancet 2010 ; 376 ( 9734 ): 23 - 32 . doi: 10.1016/S0140-6736(10)60835-5 10.1016/S0140-6736(10)60835-5 .
Myles PS , Smith JA , Forbes A , et al . Tranexamic acid in patients undergoing coronary-artery surgery . N Engl J Med 2017 ; 376 ( 2 ): 136 - 48 . doi: 10.1056/NEJMoa1606424 10.1056/NEJMoa1606424 .
Garg J , Pinnamaneni S , Aronow WS , et al . ST elevation myocardial infarction after tranexamic acid: first reported case in the United States . Am J Ther 2014 ; 21 ( 6 ): e221 - 4 . doi: 10.1097/MJT.0b013e31828fdb06 10.1097/MJT.0b013e31828fdb06 .
Gerstein NS , Brierley JK , Culling MD . Left ventricle thrombus after tranexamic acid for spine surgery in an HIV-positive patient . Spine J 2016 ; 16 ( 2 ): e77 - 82 . doi: 10.1016/j.spinee.2015.10.039 10.1016/j.spinee.2015.10.039 .
Gupta PN , Mullamalla UR , Sabin P , et al . Acute MI in a young hypertensive woman: could it be due to tranexamic acid? BMJ Case Rep 2013 ; 2013 . doi: 10.1136/bcr-2013-009979 10.1136/bcr-2013-009979 .
Günaldi M , Helvaci A , Yildirim ND , et al . Acute myocardial infarction in a patient with hemophilia A and factor V Leiden mutation . Cardiol J 2009 ; 16 ( 5 ): 458 - 61 .
Sirker A , Malik N , Bellamy M , et al . Acute myocardial infarction following tranexamic acid use in a low cardiovascular risk setting . Br J Haematol 2008 ; 141 ( 6 ): 907 - 8 . doi: 10.1111/j.1365-2141.2008.07128.x 10.1111/j.1365-2141.2008.07128.x .
Iacobellis G , Iacobellis G . Combined treatment with tranexamic acid and oral contraceptive pill causes coronary ulcerated plaque and acute myocardial infarction . Cardiovasc Drugs Ther 2004 ; 18 ( 3 ): 239 - 40 . doi: 10.1023/B:CARD.0000033646.21346.e4 10.1023/B:CARD.0000033646.21346.e4
Mekontso-Dessap A , Collet JP , Lebrun-Vignes B , et al . Acute myocardial infarction after oral tranexamic acid treatment initiation . Int J Cardiol 2002 ; 83 ( 3 ): 267 - 8 .
Roberts I . Scientific letter: could tranexamic acid use in surgery reduce perioperative myocardial infarction? Heart 2013 ; 99 ( 23 ): 1785 . doi: 10.1136/heartjnl-2013-304292 10.1136/heartjnl-2013-304292 .
Roberts I , Shakur H , Coats T , et al . The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients . Health Technol Assess 2013 ; 17 ( 10 ): 1 - 79 . doi: 10.3310/hta17100 10.3310/hta17100 .
van Diepen S , Merrill PD , Carrier M , et al . Association between CK-MB area under the curve and tranexamic acid utilization in patients undergoing coronary artery bypass surgery . J Thromb Thrombolysis 2017 ; 43 ( 4 ): 446 - 53 . doi: 10.1007/s11239-017-1480-6 10.1007/s11239-017-1480-6 .
Sule AA , Pandit N , Handa P , et al . Risk of venous thromboembolism in patients infected with HIV: a cohort study . Int J Angiol 2013 ; 22 ( 2 ): 95 - 100 . doi: 10.1055/s-0033-1333866 10.1055/s-0033-1333866 .
Luetkemeyer AF , Havlir DV , Currier JS . Complications of HIV disease and antiretroviral therapy . Top Antivir Med 2011 ; 19 : 58 - 68 .
Sullivan PS , Dworkin MS , Jones JL , et al . Epidemiology of thrombosis in HIV-infected individuals. The Adult/Adolescent Spectrum of HIV Disease Project . AIDS 2000 ; 14 ( 3 ): 321 - 4 . doi: 10.1097/00002030-200002180-00015 10.1097/00002030-200002180-00015 .
Alsolaiman MM , Chang K , Arjomand H , et al . Acute left anterior descending artery occlusion in a hemophiliac A patient during recombinant factor Ⅷ infusion: treatment with coronary angioplasty . Catheter Cardiovasc Interv 2000 ; 50 ( 4 ): 468 - 72 .
Kerkhoffs JL , Atsma DE , Oemrawsingh PV , et al . Acute myocardial infarction during substitution with recombinant factor Ⅷ concentrate in a patient with mild haemophilia A . Thromb Haemost 2004 ; 92 ( 2 ): 425 - 6 .
Mansourati J , Da Costa A , Munier S , et al . Prevalence of factor Ⅴ Leiden in patients with myocardial infarction and normal coronary angiography . Thromb Haemost 2000 ; 83 ( 6 ): 822 - 5 .
Bond L , Bevan D . Myocardial infarction in a patient with hemophilia treated with DDAVP . N Engl J Med 1988 ; 318 ( 2 ): 121 .
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