Advance in Functional Restoration of Injured Nerve with Low Level Laser and its Utilization in the Dental and Maxillofacial Region

An Pugen; Zhao Jizhi

doi:10.24920/003597

Your Location：

Home >

Browse articles >

Advance in Functional Restoration of Injured Nerve with Low Level Laser and its Utilization in the Dental and Maxillofacial Region

Chinese Medical Sciences Journal Vol. 35, Issue 3, Pages: 272-277(2020)

Review | Updated：2024-04-10

- Advance in Functional Restoration of Injured Nerve with Low Level Laser and its Utilization in the Dental and Maxillofacial Region
- Affiliations：
  
  Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  * Tel: 86-10-69156332, E-mail: zhaojizhi@126.com
- Funds：
- DOI：10.24920/003597
  CLC：
- Received：15 March 2020，
  
  Published Online：30 September 2020，
  
  Published：30 September 2020
- Accepted：
Scan QR Code
An Pugen, Zhao Jizhi. Advance in Functional Restoration of Injured Nerve with Low Level Laser and its Utilization in the Dental and Maxillofacial Region[J]. Chinese medical sciences journal, 2020, 35(3): 272-277.
DOI：

An Pugen, Zhao Jizhi. Advance in Functional Restoration of Injured Nerve with Low Level Laser and its Utilization in the Dental and Maxillofacial Region[J]. Chinese medical sciences journal, 2020, 35(3): 272-277. DOI： 10.24920/003597.

摘要

下牙槽神经和面神经是支配颌面部肌肉最重要的两条神经。下牙槽神经及面神经损伤是牙槽外科、正颌外科术后主要的并发症之一。损伤神经的功能恢复慢

治疗效果也不理想。近年的研究证实：低能量激光辅助治疗能有效恢复损伤神经的功能。在此我们总结了激光辅助治疗促进神经功能恢复的作用机制及其在颌面部神经损伤方面的临床应用。

Abstract

The inferior alveolar nerve and facial nerve are the two most important nerves in the dental and maxillofacial region. The injury to them is one of the major postoperative complications after alveolar surgery and orthognathic surgery. However

recovering the nerve function after injury takes a long time and the recovery effect tends to be unsatisfactory. In recent years

an intensively investigated technique

low level laser which has been applying in assisting the recovery of nerve function

has been gradually proved to be effective in clinically treating postoperative nerve injury. In this article we review in terms of the mechanisms involved in low level laser-assisted functional restoration of nerve injury and its clinical application in the recovery of nerve function in the dental and maxillofacial area as well.

关键词

Keywords

references

Keefe KM , Sheikh IS , Smith GM . Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury . Int J Mol Sci 2017 ; 18 ( 3 ): 548 . doi: 10.3390/ijms18030548 10.3390/ijms18030548 .

Patterson SL , Abel T , Deuel TA , et al . Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice . Neuron 1996 ; 16 ( 6 ): 1137 - 45 . DOI: 10.1016/s0896-6273(00)80140-3 http://doi.org/10.1016/s0896-6273(00)80140-3 https://www.ncbi.nlm.nih.gov/pubmed/8663990 https://www.ncbi.nlm.nih.gov/pubmed/8663990

Li R , Wu J , Lin Z , et al . Single injection of a novel nerve growth factor coacervate improves structural and functional regeneration after sciatic nerve injury in adult rats . Exp Neurol 2017 ; 288 : 1 - 10 . doi: 10.1016/j.expneurol.2016.10.015 10.1016/j.expneurol.2016.10.015 . https://www.ncbi.nlm.nih.gov/pubmed/27983992 https://www.ncbi.nlm.nih.gov/pubmed/27983992

Levi-Montalcini R . Growth control of nerve cells by a perotein factor and its antiserum: discovery of this factor may provide new leads to understanding of some neurogenetic processes . Science 1964 ; 143 ( 3602 ): 105 - 10 . doi: 10.1126/science.143.3602.105 10.1126/science.143.3602.105 . DOI: 10.1126/science.143.3602.105 http://doi.org/10.1126/science.143.3602.105 https://www.ncbi.nlm.nih.gov/pubmed/14075717 https://www.ncbi.nlm.nih.gov/pubmed/14075717

Gravvanis AI , Tsoutsos DA , Tagaris GA , et al . Beneficial effect of nerve growth factor-7S on peripheral nerve regeneration through inside-out vein grafts: an experimental study . Microsurgery 2004 ; 24 ( 5 ): 408 - 15 . doi: 10.1002/micr.20055 10.1002/micr.20055 . DOI: 10.1002/micr.20055 http://doi.org/10.1002/micr.20055 https://www.ncbi.nlm.nih.gov/pubmed/15378588 https://www.ncbi.nlm.nih.gov/pubmed/15378588

Yazdani SO , Golestaneh AF , Shafiee A , et al . Effects of low level laser therapy on proliferation and neurotrophic factor gene expression of human schwann cells in vitro . J Photochem Photobiol B 2012 ; 107 : 9 - 13 . doi: 10.1016/j.jphotobiol.2011.11.001 10.1016/j.jphotobiol.2011.11.001 . https://www.ncbi.nlm.nih.gov/pubmed/22178388 https://www.ncbi.nlm.nih.gov/pubmed/22178388

Kim HS , Lee J , Lee DY , et al . Schwann cell precursors from human pluripotent stem cells as a potential therapeutic target for myelin repair . Stem Cell Reports 2017 ; 8 ( 6 ): 1714 - 26 . doi: 10.1016/j.stemcr.2017.04.011 10.1016/j.stemcr.2017.04.011 . DOI: 10.1016/j.stemcr.2017.04.011 http://doi.org/10.1016/j.stemcr.2017.04.011 https://www.ncbi.nlm.nih.gov/pubmed/28506533 https://www.ncbi.nlm.nih.gov/pubmed/28506533

Day AGE , Bhangra KS , Murray-Dunning C , et al . The effect of hypothermic and cryogenic preservation on engineered neural tissue . Tissue Eng Part C Methods 2017 ; 23 ( 10 ): 575 - 82 . doi: 10.1089/ten.tec.2017.0244 10.1089/ten.tec.2017.0244 . DOI: 10.1089/ten.TEC.2017.0244 http://doi.org/10.1089/ten.TEC.2017.0244 https://www.ncbi.nlm.nih.gov/pubmed/28877649 https://www.ncbi.nlm.nih.gov/pubmed/28877649

Shadiack AM , Sun Y , Zigmond RE . Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons . J Neurosci 2001 ; 21 ( 2 ): 363 - 71 . doi: 10.1523/JNEUROSCI.21-02-00363.2001 10.1523/JNEUROSCI.21-02-00363.2001 . https://www.ncbi.nlm.nih.gov/pubmed/11160417 https://www.ncbi.nlm.nih.gov/pubmed/11160417

Chen ZW , Wang MS . Effects of nerve growth factor on crushed sciatic nerve regeneration in rats . Microsurgery 1995 ; 16 ( 8 ): 547 - 51 . doi: 10.1002/micr.1920160808 10.1002/micr.1920160808 . DOI: 10.1002/micr.1920160808 http://doi.org/10.1002/micr.1920160808 https://www.ncbi.nlm.nih.gov/pubmed/8538432 https://www.ncbi.nlm.nih.gov/pubmed/8538432

Pezet S , Malcangio M , Mcmahon SB . BDNF: a neuromodulator in nociceptive pathways? Brain Res Brain Res Rev 2002 ; 40 ( 1-3 ): 240 - 9 . doi: 10.1016/s0165-0173(02)00206-0 10.1016/s0165-0173(02)00206-0 . DOI: 10.1016/s0165-0173(02)00206-0 http://doi.org/10.1016/s0165-0173(02)00206-0 https://www.ncbi.nlm.nih.gov/pubmed/12589922 https://www.ncbi.nlm.nih.gov/pubmed/12589922

Fukuoka T , Kondo E , Dai Y , et al . Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model . J Neurosci 2001 ; 21 ( 13 ): 4891 - 900 . doi: 10.1523/JNEUROSCI.21-13-04891.2001 10.1523/JNEUROSCI.21-13-04891.2001 . https://www.ncbi.nlm.nih.gov/pubmed/11425916 https://www.ncbi.nlm.nih.gov/pubmed/11425916

Wang X , Ratnam J , Zou B , et al . TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain . J Neurosci 2009 ; 29 ( 17 ): 5508 - 15 . doi: 10.1523/jneurosci.4288-08.2009 10.1523/jneurosci.4288-08.2009 . https://www.ncbi.nlm.nih.gov/pubmed/19403818 https://www.ncbi.nlm.nih.gov/pubmed/19403818

Zhou XF , Deng YS , Xian CJ , et al . Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats . Eur J Neurosci 2000 ; 12 ( 1 ): 100 - 5 . doi: 10.1046/j.1460-9568.2000.00884.x 10.1046/j.1460-9568.2000.00884.x . DOI: 10.1046/j.1460-9568.2000.00884.x http://doi.org/10.1046/j.1460-9568.2000.00884.x https://www.ncbi.nlm.nih.gov/pubmed/10651864 https://www.ncbi.nlm.nih.gov/pubmed/10651864

de Oliveira Martins D , Martinez Dos Santos F , Evany De Oliveira M , et al . Laser therapy and pain-related behavior after injury of the inferior alveolar nerve: possible involvement of neurotrophins . J Neurotrauma 2013 ; 30 ( 6 ): 480 - 6 . doi: 10.1089/neu.2012.2603 10.1089/neu.2012.2603 . DOI: 10.1089/neu.2012.2603 http://doi.org/10.1089/neu.2012.2603 https://www.ncbi.nlm.nih.gov/pubmed/23190308 https://www.ncbi.nlm.nih.gov/pubmed/23190308

Buchaim RL , Andreo JC , Barraviera B , et al . Effect of low-level laser therapy (LLLT) on peripheral nerve regeneration using fibrin glue derived from snake venom . Injury 2015 ; 46 ( 4 ): 655 - 60 . doi: 10.1016/j.injury.2015.01.031 10.1016/j.injury.2015.01.031 . DOI: 10.1016/j.injury.2015.01.031 http://doi.org/10.1016/j.injury.2015.01.031 https://www.ncbi.nlm.nih.gov/pubmed/25669962 https://www.ncbi.nlm.nih.gov/pubmed/25669962

Dias FJ , Fazan VPS , Cury DP , et al . Growth factors expression and ultrastructural morphology after application of low-level laser and natural latex protein on a sciatic nerve crush-type injury . 2019 ; 14 ( 1 ): e210211 . doi: 10.1371/journal.pone.0210211 10.1371/journal.pone.0210211 .

Buchaim DV , Andreo JC , Ferreira Junior RS , et al . Efficacy of laser photobiomodulation on morphological and functional repair of the facial nerve . Photomed Laser Surg 2017 ; 35 ( 8 ): 442 - 9 . doi: 10.1089/pho.2016.4204 10.1089/pho.2016.4204 . DOI: 10.1089/pho.2016.4204 http://doi.org/10.1089/pho.2016.4204 https://www.ncbi.nlm.nih.gov/pubmed/28557664 https://www.ncbi.nlm.nih.gov/pubmed/28557664

Mashhoudi Barez M , Tajziehchi M , Heidari MH , et al . Stimulation effect of low level laser therapy on sciatic nerve regeneration in rat . J Lasers Med Sci 2017 ; 8 ( Suppl 1 ): S32 - S7 . doi: 10.15171/jlms.2017.s7 10.15171/jlms.2017.s7 . DOI: 10.15171/jlms.2017.s7 http://doi.org/10.15171/jlms.2017.s7 https://www.ncbi.nlm.nih.gov/pubmed/29071033 https://www.ncbi.nlm.nih.gov/pubmed/29071033

Bloom JD , Bleier BS , Goldstein SA , et al . Laser facial nerve welding in a rabbit model . Arch Facial Plast Surg 2012 ; 14 ( 1 ): 52 - 8 . doi: 10.1001/archfacial.2011.61 10.1001/archfacial.2011.61 . https://www.ncbi.nlm.nih.gov/pubmed/21844481 https://www.ncbi.nlm.nih.gov/pubmed/21844481

Bhatt NK , Khan TR , Mejias C , et al . Nerve transection repair using laser-activated chitosan in a rat model . Laryngoscope 2017 ; 127 ( 8 ): E253 - E7 . doi: 10.1002/lary.26583 10.1002/lary.26583 . DOI: 10.1002/lary.26583 http://doi.org/10.1002/lary.26583 https://www.ncbi.nlm.nih.gov/pubmed/28349572 https://www.ncbi.nlm.nih.gov/pubmed/28349572

Curtis NJ , Owen E , Walker DM , et al . Comparison of microsuture, interpositional nerve graft, and laser solder weld repair of the rat inferior alveolar nerve . J Oral Maxillofac Surg 2011 ; 69 ( 6 ): e246 - e55 . doi: 10.1016/j.joms.2011.02.007 10.1016/j.joms.2011.02.007 . DOI: 10.1016/j.joms.2011.02.007 http://doi.org/10.1016/j.joms.2011.02.007 https://www.ncbi.nlm.nih.gov/pubmed/21605793 https://www.ncbi.nlm.nih.gov/pubmed/21605793

Menovsky T , Beek JF . Carbon dioxide laser-assisted nerve repair: effect of solder and suture material on nerve regeneration in rat sciatic nerve . Microsurgery 2003 ; 23 ( 2 ): 109 - 16 . doi: 10.1002/micr.10100 10.1002/micr.10100 . DOI: 10.1002/micr.10100 http://doi.org/10.1002/micr.10100 https://www.ncbi.nlm.nih.gov/pubmed/12740882 https://www.ncbi.nlm.nih.gov/pubmed/12740882

Steel B . Lingual split versus surgical bur technique in the extraction of impacted mandibular third molars: a systematic review . Oral Surg Oral Med Oral Pathol Oral Radiol 2012 ; 114 ( 3 ): 294 - 302 . doi: 10.1016/j.tripleo.2011.07.028 10.1016/j.tripleo.2011.07.028 . DOI: 10.1016/j.tripleo.2011.07.028 http://doi.org/10.1016/j.tripleo.2011.07.028 https://www.ncbi.nlm.nih.gov/pubmed/22883979 https://www.ncbi.nlm.nih.gov/pubmed/22883979

Kim YK , Kim SG , Kim JH . Altered sensation after orthognathic surgery . J Oral Maxillofac Surg 2011 ; 69 ( 3 ): 893 - 8 . doi: 10.1016/j.joms.2010.10.025 10.1016/j.joms.2010.10.025 . https://www.ncbi.nlm.nih.gov/pubmed/21211888 https://www.ncbi.nlm.nih.gov/pubmed/21211888

Mohajerani SH , Tabeie F , Bemanali M , et al . Effect of low-level laser and light-emitting diode on inferior alveolar nerve recovery after sagittal split osteotomy of the mandible . J Craniofac Surg 2017 ; 28 ( 4 ): e408 - e11 . doi: 10.1097/SCS.0000000000002929 10.1097/SCS.0000000000002929 . https://www.ncbi.nlm.nih.gov/pubmed/28538060 https://www.ncbi.nlm.nih.gov/pubmed/28538060

Gasperini G , de Siqueira ICR , Costa LR . Lower-level laser therapy improves neurosensory disorders resulting from bilateral mandibular sagittal split osteotomy: a randomized crossover clinical trial . J Craniomaxillofac Surg 2014 ; 42 ( 5 ): e130 - e3 . doi: 10.1016/j.jcms.2013.07.009 10.1016/j.jcms.2013.07.009 . DOI: 10.1016/j.jcms.2013.07.009 http://doi.org/10.1016/j.jcms.2013.07.009 https://www.ncbi.nlm.nih.gov/pubmed/24011464 https://www.ncbi.nlm.nih.gov/pubmed/24011464

Fuhrer-Valdivia A , Noguera-Pantoja A , Ramirez-Lobos V , et al . Low-level laser effect in patients with neurosensory impairment of mandibular nerve after sagittal split ramus osteotomy. Randomized clinical trial, controlled by placebo . Med Oral Patol Oral Cir Bucal 2014 ; 19 ( 4 ): e327 - e34 . doi: 10.4317/medoral.19626 10.4317/medoral.19626 . DOI: 10.4317/medoral.19626 http://doi.org/10.4317/medoral.19626 https://www.ncbi.nlm.nih.gov/pubmed/24608207 https://www.ncbi.nlm.nih.gov/pubmed/24608207

Guarini D , Gracia B , Ramírez-Lobos V , et al . Laser biophotomodulation in patients with neurosensory disturbance of the inferior alveolar nerve after sagittal split ramus osteotomy: a 2-year follow-up study . Photomed Laser Surg 2018 ; 36 ( 1 ): 3 - 9 . doi: 10.1089/pho.2017.4312 10.1089/pho.2017.4312 . DOI: 10.1089/pho.2017.4312 http://doi.org/10.1089/pho.2017.4312 https://www.ncbi.nlm.nih.gov/pubmed/29022844 https://www.ncbi.nlm.nih.gov/pubmed/29022844

Schultze-Mosgau S , Reich RH . Assessment of inferior alveolar and lingual nerve disturbances after dentoalveolar surgery, and of recovery of sensitivity . Int J Oral Maxillofac Surg 1993 ; 22 ( 4 ): 214 - 7 . doi: 10.1016/s0901-5027(05)80638-1 10.1016/s0901-5027(05)80638-1 . DOI: 10.1016/s0901-5027(05)80638-1 http://doi.org/10.1016/s0901-5027(05)80638-1 https://www.ncbi.nlm.nih.gov/pubmed/8409561 https://www.ncbi.nlm.nih.gov/pubmed/8409561

Pol R , Gallesio G , Riso M , et al . Effects of superpulsed, low-level laser therapy on neurosensory recovery of the inferior alveolar nerve . J Craniofac Surg 2016 ; 27 ( 5 ): 1215 - 9 . doi: 10.1097/SCS.0000000000002757 10.1097/SCS.0000000000002757 . https://www.ncbi.nlm.nih.gov/pubmed/27391492 https://www.ncbi.nlm.nih.gov/pubmed/27391492

Spencer CR , Irving RM . Causes and management of facial nerve palsy . Br J Hosp Med (Lond) 2016 ; 77 ( 12 ): 686 - 91 . doi: 10.12968/hmed.2016.77.12.686 10.12968/hmed.2016.77.12.686 . DOI: 10.12968/hmed.2016.77.12.686 http://doi.org/10.12968/hmed.2016.77.12.686 http://www.magonlinelibrary.com/doi/10.12968/hmed.2016.77.12.686 http://www.magonlinelibrary.com/doi/10.12968/hmed.2016.77.12.686

Ferreira M , Marques EE , Duarte JA , et al . Physical therapy with drug treatment in Bell palsy: a focused review . Am J Phys Med Rehabil 2015 ; 94 ( 4 ): 331 - 40 . doi: 10.1097/phm.0000000000000255 10.1097/phm.0000000000000255 . DOI: 10.1097/PHM.0000000000000255 http://doi.org/10.1097/PHM.0000000000000255 https://www.ncbi.nlm.nih.gov/pubmed/25785922 https://www.ncbi.nlm.nih.gov/pubmed/25785922

Holland NJ , Bernstein JM . Bell’s palsy . BMJ Clin Evid 2014 ; 2014 : 1204 . https://www.ncbi.nlm.nih.gov/pubmed/24717284 https://www.ncbi.nlm.nih.gov/pubmed/24717284

Lampert L , Wong YJ . Combined antiviral-corticosteroid therapy for Bell palsy yields inconclusive benefit . J Am Dent Assoc 2012 ; 143 ( 1 ): 57 - 8 . doi: 10.14219/jada.archive.2012.0020 10.14219/jada.archive.2012.0020 . DOI: 10.1136/bmj.b3354 http://doi.org/10.1136/bmj.b3354 http://dx.doi.org/10.1136/bmj.b3354 http://dx.doi.org/10.1136/bmj.b3354

Fontana CR , Bagnato VS . Low-level laser therapy in pediatric Bell’s palsy: case report in a three-year-old child . J Altern Complement Med 2013 ; 19 ( 4 ): 376 - 82 . doi: 10.1089/acm.2011.0531 10.1089/acm.2011.0531 . DOI: 10.1089/acm.2011.0531 http://doi.org/10.1089/acm.2011.0531 https://www.ncbi.nlm.nih.gov/pubmed/23140111 https://www.ncbi.nlm.nih.gov/pubmed/23140111

Ordahan B , Karahan AY . Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell’s) palsy . Lasers Med Sci 2017 ; 32 ( 4 ): 931 - 6 . doi: 10.1007/s10103-017-2195-9 10.1007/s10103-017-2195-9 . DOI: 10.1007/s10103-017-2195-9 http://doi.org/10.1007/s10103-017-2195-9 https://www.ncbi.nlm.nih.gov/pubmed/28337563 https://www.ncbi.nlm.nih.gov/pubmed/28337563

Alayat MSM , Elsodany AM , El Fiky AAR . Efficacy of high and low level laser therapy in the treatment of Bell’s palsy: a randomized double blind placebo-controlled trial . Lasers Med Sci 2014 ; 29 ( 1 ): 335 - 42 . doi: 10.1007/s10103-013-1352-z 10.1007/s10103-013-1352-z . DOI: 10.1007/s10103-013-1352-z http://doi.org/10.1007/s10103-013-1352-z http://link.springer.com/10.1007/s10103-013-1352-z http://link.springer.com/10.1007/s10103-013-1352-z

Views

488

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰