Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review

Zhao Jie; Yang Yimeng; Ming Shuhong

doi:10.24920/003603

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Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review

Chinese Medical Sciences Journal Vol. 35, Issue 4, Pages: 371-376(2020)

Case Report | Updated：2024-04-10

- Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review
- Affiliations：
  
  1. 1Department of Medical Oncology, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
  2. 2Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China
- Author bio：
  
  * E-mail: qzf301@sohu.com; Tel: 86-17801204737.
- Funds：
- DOI：10.24920/003603
  CLC：
- Received：08 May 2019，
  
  Accepted：2019-9-6，
  
  Published Online：31 December 2020，
  
  Published：31 December 2020
- Accepted：
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Zhao Jie, Yang Yimeng, Ming Shuhong. Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review[J]. Chinese medical sciences journal, 2020, 35(4): 371-376.
DOI：

Zhao Jie, Yang Yimeng, Ming Shuhong. Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review[J]. Chinese medical sciences journal, 2020, 35(4): 371-376. DOI： 10.24920/003603.

摘要

噬血细胞性淋巴组织细胞增生症（hemophagocytic lymphohistiocytosis

HLH）是一种罕见但严重威胁健康的疾病

其典型特征为免疫反应失调和过度的炎症反应。目前关于妊娠引起的HLH鲜有报道。本文报道了一例自怀孕17周以来持续发烧21天的30岁孕妇

通过一系列详尽的检查排除感染、自身免疫性疾病和恶性肿瘤等可能病因

给予广谱抗生素和地塞米松等治疗后

病情仍在进展。患者被诊断为妊娠引起的HLH。终止妊娠并继续使用糖皮质激素控制过度炎症反应后

该患者疾病痊愈。妊娠引起的HLH若不及时给予有效的治疗

会严重威胁生命健康。进一步研究以提高HLH早期诊断和病因鉴定至关重要。

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare but devastating disease characterized by dysregulated immune response and hyperinflammation. To our knowledge

pregnancy-induced HLH has been rarely reported in the literature. A 30-year-old pregnant woman presented persistent fever for 21 days since 17 weeks of pregnancy. The possible etiologies such as infection

autoimmune disorder

and malignancy had been ruled out based on a series of exhaustive examinations. The disease progressed despite the use of broad-spectrum antibiotics and dexamethasone. The patient was diagnosed as pregnancy-induced HLH

and finally recovered completely after termination of pregnancy by caesarean and the continuous use of glucocorticoid which played a crucial part in controlling hyperinflammation. Pregnancy-induced HLH could be fatal if effective treatment was not initiated timely. Further studies are needed to improve early diagnosis and etiology identification of HLH.

关键词

Keywords

references

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