Wnt5a Plays Controversial Roles in Cancer Progression

Chen Xu; Liu Hongling; Zhao Fenghui; Jiao Zongxian; Wang Jinsui; Dang Yamei

doi:10.24920/003659

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Wnt5a Plays Controversial Roles in Cancer Progression

Chinese Medical Sciences Journal Vol. 35, Issue 4, Pages: 357-365(2020)

Review | Updated：2024-04-10

- Wnt5a Plays Controversial Roles in Cancer Progression
- Affiliations：
  
  1. 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
  2. 2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
  3. 3Pathological Institution of Basic Medical College, Lanzhou University, Lanzhou 730000, China
- Author bio：
  
  * E-mail: zhaofh0931@163.com.
- Funds：
- DOI：10.24920/003659
  CLC：
- Received：12 September 2019，
  
  Accepted：2020-2-4，
  
  Published Online：31 December 2020，
  
  Published：31 December 2020
- Accepted：
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Chen Xu, Liu Hongling, Zhao Fenghui, et al. Wnt5a Plays Controversial Roles in Cancer Progression[J]. Chinese medical sciences journal, 2020, 35(4): 357-365.
DOI：

Chen Xu, Liu Hongling, Zhao Fenghui, et al. Wnt5a Plays Controversial Roles in Cancer Progression[J]. Chinese medical sciences journal, 2020, 35(4): 357-365. DOI： 10.24920/003659.

摘要

Wnt5a是Wnt家族中一种具有代表性的分子

它通过Wnt非经典途径调控多种细胞功能。虽然Wnt5a在多种病理状态中均有涉及

但其在肿瘤中的作用尚不明确。Wnt5a在肿瘤的作用机制中可能涉及甲基化修饰、不同的mRNA亚型以及调控不同的下游通路。因此

Wnt5a在肿瘤发展起重要作用（侵袭、迁移、增殖、以及上皮-间质转化）

是一个潜在的预后和治疗的生物标志物。

Abstract

Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions

its role in cancer is ambiguous and might involve methyl modifications

distinct mRNA isoforms

as well as different downstream pathways. Therefore

it is an essential factor in cancers’ progression (invasion

migration

proliferation

and epithelial-mesenchymal transition)

and a potential biomarker for prognosis and treatment.

关键词

Keywords

references

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