Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review

Liu Jieyu; Wang Jiaxiang; Xu Li; Deng Feiyan

doi:10.24920/003729

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Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review

Chinese Medical Sciences Journal Vol. 36, Issue 2, Pages: 135-149(2021)

Review | Updated：2024-04-10

- Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review
- Affiliations：
  
  1Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
  2Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
  3Department of Epidemiology and Biostatics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
- Author bio：
  
  *Tel: 86-512-65882252, E-mail: fdeng@suda.edu.cn
- Funds：
- DOI：10.24920/003729
  CLC：
- Received：13 September 2020，
  
  Published Online：29 December 2020，
  
  Published：30 June 2021
- Accepted：
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Liu Jieyu, Wang Jiaxiang, Xu Li, et al. Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review[J]. Chinese medical sciences journal, 2021, 36(2): 135-149.
DOI：

Liu Jieyu, Wang Jiaxiang, Xu Li, et al. Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review[J]. Chinese medical sciences journal, 2021, 36(2): 135-149. DOI： 10.24920/003729.

摘要

骨质疏松症是一种系统性的慢性骨骼疾病

其特征为骨矿密度低、骨质疏松性骨折风险升高。骨质疏松症好发于中老年人群

尤其是绝经后妇女。伴随着人口老龄化

骨质疏松症已成为全球范围内严重的公共卫生问题。尽早识别高危人群、及时有效的干预和治疗对于预防骨质疏松性骨折至关重要。鉴于骨质疏松症的遗传率较高且发病机制复杂

有必要综合考虑重要的生物分子、从而对骨质疏松性骨折进行准确的风险评估。为此

我们总结回顾了可用于骨质疏松性骨折风险评估的潜在生物分子及其最新研究进展。未来对于这些生物分子的系统评估有助于研发新的方法和检测策略

比如开发生物芯片

以应用于骨质疏松症的早期识别和骨质疏松性骨折的预防。

Abstract

Osteoporosis as a systemic chronic skeletal disease is characterized by low bone mineral density and increased risk to osteoporotic fractures. Osteoporosis is prevalent in the middle-aged and elderly population

especially in the postmenopausal women. With population aging

osteoporosis has become a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing osteoporotic fractures. In light of the high heritability and complex pathogenesis of osteoporosis

comprehensive consideration of vital biological/biochemical factors is necessary for accurate risk evaluation of fractures. For this purpose

we review recent research progress on molecules which can be applied to assess risk for osteoporotic fractures. Future integrative analyses and systematic evaluation of these molecules may facilitate developing novel methodologies and/or test strategies

i.e.

biochips

for early recognition of osteoporosis

hence contributing to preventing osteoporotic fractures.

关键词

Keywords

references

Briggs AM , Cross MJ , Hoy DG . et al . Musculoskeletal health conditions represent a global threat to healthy aging: a report for the 2015 World Health Organization World Report on Ageing and Health . Gerontologist 2016 ; 56 Suppl 2 : S243 - 55 . doi: 10.1093/geront/gnw002 1001-9294-36-2-135/geront/gnw002 . DOI: 10.1093/geront/gnw002 http://doi.org/10.1093/geront/gnw002

Hinz L , Freiheit E , Kline G . How good is our best guess? Clinical application of the WHO FRAX tool in osteoporotic fracture risk determination and treatment decisions . Calcif Tissue Int 2016 ; 99 ( 2 ): 114 - 20 . doi: 10.1007/s00223-016-0134-6 1001-9294-36-2-135/s00223-016-0134-6 . DOI: 10.1007/s00223-016-0134-6 http://doi.org/10.1007/s00223-016-0134-6 http://link.springer.com/10.1007/s00223-016-0134-6 http://link.springer.com/10.1007/s00223-016-0134-6

Liu SY , Huang M , Chen R , et al . Comparison of strategies for setting intervention thresholds for Chinese postmenopausal women using the FRAX model . Endocrine 2019 ; 65 ( 1 ): 200 - 6 . doi: 10.1007/s12020-019-01951-8 1001-9294-36-2-135/s12020-019-01951-8 . DOI: 10.1007/s12020-019-01951-8 http://doi.org/10.1007/s12020-019-01951-8 https://doi.org/10.1007/s12020-019-01951-8 https://doi.org/10.1007/s12020-019-01951-8

Su Y , Leung J , Kwok T . The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong . Osteoporos Int 2018 ; 29 ( 2 ): 355 - 63 . doi: 10.1007/s00198-017-4373-9 1001-9294-36-2-135/s00198-017-4373-9 . DOI: 10.1007/s00198-017-4277-8 http://doi.org/10.1007/s00198-017-4277-8

Estrada K , Styrkarsdottir U , Evangelou E , et al . Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture . Nat Genet 2012 ; 44 ( 5 ): 491 - 501 . doi: 10.1038/ng.2249 1001-9294-36-2-135/ng.2249 . DOI: 10.1038/ng.2249 http://doi.org/10.1038/ng.2249 https://doi.org/10.1038/ng.2249 https://doi.org/10.1038/ng.2249

Kemp JP , Morris JA , Medina-Gomez C . et al . Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis . Nat Genet 2017 ; 49 ( 10 ): 1468 - 75 . doi: 10.1038/ng.3949 1001-9294-36-2-135/ng.3949 . DOI: 10.1038/ng.3949 http://doi.org/10.1038/ng.3949 http://www.nature.com/articles/ng.3949 http://www.nature.com/articles/ng.3949

Cauley JA . Osteoporosis: fracture epidemiology update 2016 . Curr Opin Rheumatol 2017 ; 29 ( 2 ): 150 - 6 . doi: 10.1097/BOR.0000000000000365 1001-9294-36-2-135/BOR.0000000000000365 . DOI: 10.1097/BOR.0000000000000365 http://doi.org/10.1097/BOR.0000000000000365

Liu X , Xu X . MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression . Int J Mol Med 2018 ; 42 ( 2 ): 1026 - 33 . doi: 10.3892/ijmm.2018.3690 1001-9294-36-2-135/ijmm.2018.3690 . DOI: 10.3892/ijmm.2018.3690 http://doi.org/10.3892/ijmm.2018.3690

Lundin H , Sääf M , Strender LE , et al . High serum insulin-like growth factor-binding protein 1 (IGFBP-1) is associated with high fracture risk independent of insulin-like growth factor 1 (IGF-I) . Calcif Tissue Int 2016 ; 99 ( 4 ): 333 - 9 . doi: 10.1007/s00223-016-0152-4 1001-9294-36-2-135/s00223-016-0152-4 . DOI: 10.1007/s00223-016-0152-4 http://doi.org/10.1007/s00223-016-0152-4 http://link.springer.com/10.1007/s00223-016-0152-4 http://link.springer.com/10.1007/s00223-016-0152-4

Rousseau JC , Sornay-Rendu E , Bertholon C , et al . Serum periostin is associated with fracture risk in postmenopausal women: a 7-year prospective analysis of the OFELY study . J Clin Endocrinol Metab 2014 ; 99 ( 7 ): 2533 - 9 . doi: 10.1210/jc.2013-3893 1001-9294-36-2-135/jc.2013-3893 . DOI: 10.1210/jc.2013-3893 http://doi.org/10.1210/jc.2013-3893

Bonnet N , Biver E , Chevalley T , et al . Serum Levels of a cathepsin-K generated periostin fragment predict incident low-trauma fractures in postmenopausal women independently of BMD and FRAX . J Bone Miner Res 2017 ; 32 ( 11 ): 2232 - 8 . doi: 10.1002/jbmr.3203 1001-9294-36-2-135/jbmr.3203 . DOI: 10.1002/jbmr.3203 http://doi.org/10.1002/jbmr.3203 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.3203 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.3203

Johansson H , Oden A , Lerner UH . et al . High serum adiponectin predicts incident fractures in elderly men: osteoporotic fractures in men (MrOS) Sweden . J Bone Miner Res 2012 ; 27 ( 6 ): 1390 - 6 . doi: 10.1002/jbmr.1591 1001-9294-36-2-135/jbmr.1591 . DOI: 10.1002/jbmr.1591 http://doi.org/10.1002/jbmr.1591

Johansson H , Oden A , Karlsson MK . et al . Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden . Osteoporos Int 2014 ; 25 ( 7 ): 1831 - 6 . doi: 10.1007/s00198-014-2654-0 1001-9294-36-2-135/s00198-014-2654-0 . DOI: 10.1007/s00198-014-2654-0 http://doi.org/10.1007/s00198-014-2654-0

Oei L , Campos-Obando N , Dehghan A . et al . Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study . Osteoporos Int 2014 ; 25 ( 4 ): 1247 - 54 . doi: 10.1007/s00198-013-2578-0 1001-9294-36-2-135/s00198-013-2578-0 . DOI: 10.1007/s00198-013-2578-0 http://doi.org/10.1007/s00198-013-2578-0

Tamaki J , Iki M , Kadowaki E . et al . Biochemical markers for bone turnover predict risk of vertebral fractures in postmenopausal women over 10 years: the Japanese Population-Based Osteoporosis (JPOS) Cohort Study . Osteoporos Int 2013 ; 24 ( 3 ): 887 - 97 . doi: 10.1007/s00198-012-2106-7 1001-9294-36-2-135/s00198-012-2106-7 . DOI: 10.1007/s00198-012-2106-7 http://doi.org/10.1007/s00198-012-2106-7

Mirza MA , Karlsson MK , Mellstrom D , et al . Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men . J Bone Miner Res 2011 ; 26 ( 4 ): 857 - 64 . doi: 10.1002/jbmr.263 1001-9294-36-2-135/jbmr.263 . DOI: 10.1002/jbmr.263 http://doi.org/10.1002/jbmr.263

Lane NE , Parimi N , Corr M , et al . Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study . J Bone Miner Res 2013 ; 28 ( 11 ): 2325 - 32 . doi: 10.1002/jbmr.1985 1001-9294-36-2-135/jbmr.1985 . DOI: 10.1002/jbmr.1985 http://doi.org/10.1002/jbmr.1985 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.1985 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.1985

Szulc P , Bertholon C , Borel O , et al . Lower fracture risk in older men with higher sclerostin concentration: a prospective analysis from the MINOS study . J Bone Miner Res 2013 ; 28 ( 4 ): 855 - 64 . doi: 10.1002/jbmr.1823 1001-9294-36-2-135/jbmr.1823 . DOI: 10.1002/jbmr.1823 http://doi.org/10.1002/jbmr.1823 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.1823 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.1823

Tamaki J , Kouda K , Fujita Y , et al . Ratio of endogenous secretory receptor for advanced glycation end products to pentosidine predicts fractures in men . J Clin Endocrinol Metab 2018 ; 103 ( 1 ): 85 - 94 . doi: 10.1210/jc.2017-00929 1001-9294-36-2-135/jc.2017-00929 . DOI: 10.1210/jc.2017-00929 http://doi.org/10.1210/jc.2017-00929

Garnero P , Hausherr E , Chapuy MC , et al . Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study . J Bone Miner Res 1996 ; 11 ( 10 ): 1531 - 8 . doi: 10.1002/jbmr.5650111021 1001-9294-36-2-135/jbmr.5650111021 . DOI: 10.1002/jbmr.5650111021 http://doi.org/10.1002/jbmr.5650111021

Garnero P , Cloos P , Sornay-Rendu E , et al . Type I collagen racemization and isomerization and the risk of fracture in postmenopausal women: the OFELY prospective study . J Bone Miner Res 2002 ; 17 ( 5 ): 826 - 33 . doi: 10.1359/jbmr.2002.17.5.826 1001-9294-36-2-135/jbmr.2002.17.5.826 . DOI: 10.1359/jbmr.2002.17.5.826 http://doi.org/10.1359/jbmr.2002.17.5.826 http://doi.wiley.com/10.1359/jbmr.2002.17.5.826 http://doi.wiley.com/10.1359/jbmr.2002.17.5.826

Yoshimura N , Muraki S , Oka H , et al . Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort . Mod Rheumatol 2011 ; 21 ( 6 ): 608 - 20 . doi: 10.1007/s10165-011-0455-2 1001-9294-36-2-135/s10165-011-0455-2 . DOI: 10.1007/s10165-011-0455-2 http://doi.org/10.1007/s10165-011-0455-2

Gossiel F , Scott JR , Paggiosi MA , et al . Effect of teriparatide treatment on circulating periostin and its relationship to regulators of bone formation and BMD in postmenopausal women with osteoporosis . J Clin Endocrinol Metab 2018 ; 103 ( 4 ): 1302 - 9 . doi: 10.1210/jc.2017-00283 1001-9294-36-2-135/jc.2017-00283 . DOI: 10.1210/jc.2017-00283 http://doi.org/10.1210/jc.2017-00283

Meesters DM , Wijnands KAP , Brink PRG , et al . Malnutrition and fracture healing: are specific deficiencies in amino acids important in nonunion development? Nutrients 2018 ; 10 ( 11 ): 1597 . doi: 10.3390/nu10111597 1001-9294-36-2-135/nu10111597 . DOI: 10.3390/nu10111597 http://doi.org/10.3390/nu10111597 http://www.mdpi.com/2072-6643/10/11/1597 http://www.mdpi.com/2072-6643/10/11/1597

Gjesdal CG , Vollset SE , Ueland PM , et al . Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study . J Bone Miner Res 2007 ; 22 ( 5 ): 747 - 56 . doi: 10.1359/jbmr.070210 1001-9294-36-2-135/jbmr.070210 . DOI: 10.1359/jbmr.070210 http://doi.org/10.1359/jbmr.070210

Enneman AW , van der Velde N , de Jonge R , et al . The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures . Bone 2012 ; 50 ( 6 ): 1401 - 5 . doi: 10.1016/j.bone.2012.03.013 1001-9294-36-2-135/j.bone.2012.03.013 . DOI: 10.1016/j.bone.2012.03.013 http://doi.org/10.1016/j.bone.2012.03.013

Øyen J , Svingen GF , Gjesdal CG , et al . Plasma dimethylglycine, nicotine exposure and risk of low bone mineral density and hip fracture: the Hordaland Health Study . Osteoporos Int 2015 ; 26 ( 5 ): 1573 - 83 . doi: 10.1007/s00198-015-3030-4 1001-9294-36-2-135/s00198-015-3030-4 . DOI: 10.1007/s00198-015-3030-4 http://doi.org/10.1007/s00198-015-3030-4

Cabrera D , Kruger M , Wolber FM , et al . Association of plasma lipids and polar metabolites with low bone mineral density in Singaporean-Chinese menopausal women: a pilot study . Int J Environ Res Public Health 2018 ; 15 ( 5 ): 1045 . doi: 10.3390/ijerph15051045 1001-9294-36-2-135/ijerph15051045 . DOI: 10.3390/ijerph15051045 http://doi.org/10.3390/ijerph15051045 http://www.mdpi.com/1660-4601/15/5/1045 http://www.mdpi.com/1660-4601/15/5/1045

Lecka-Czernik B , Baroi S , Stechschulte LA , et al . Marrow fat-a new target to treat bone diseases? Curr Osteoporos Rep 2018 ; 16 ( 2 ): 123 - 9 . doi: 10.1007/s11914-018-0426-z 1001-9294-36-2-135/s11914-018-0426-z . DOI: 10.1007/s11914-018-0426-z http://doi.org/10.1007/s11914-018-0426-z

Ahn SH , Koh JM , Gong EJ , et al . Association of bone marrow sphingosine 1-phosphate levels with osteoporotic hip fractures . J Bone Metab 2013 ; 20 ( 2 ): 61 - 5 . doi: 10.11005/jbm.2013.20.2.61 1001-9294-36-2-135/jbm.2013.20.2.61 . DOI: 10.11005/jbm.2013.20.2.61 http://doi.org/10.11005/jbm.2013.20.2.61 https://synapse.koreamed.org/DOIx.php?id=10.11005/jbm.2013.20.2.61 https://synapse.koreamed.org/DOIx.php?id=10.11005/jbm.2013.20.2.61

Ardawi MM , Rouzi AA , Al-Senani NS , et al . High plasma sphingosine 1-phosphate levels predict osteoporotic fractures in postmenopausal women: the center of excellence for osteoporosis research study . J Bone Metab 2018 ; 25 ( 2 ): 87 - 98 . doi: 10.11005/jbm.2018.25.2.87 1001-9294-36-2-135/jbm.2018.25.2.87 . DOI: 10.11005/jbm.2018.25.2.87 http://doi.org/10.11005/jbm.2018.25.2.87 https://synapse.koreamed.org/DOIx.php?id=10.11005/jbm.2018.25.2.87 https://synapse.koreamed.org/DOIx.php?id=10.11005/jbm.2018.25.2.87

Ginsberg C , Katz R , de Boer IH , et al . The 24, 25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: the cardiovascular health study . Bone 2018 ; 107 : 124 - 30 . doi: 10.1016/j.bone.2017.11.011 1001-9294-36-2-135/j.bone.2017.11.011 . DOI: S8756-3282(17)30430-1 http://doi.org/S8756-3282(17)30430-1

Swanson CM ., Srikanth P , Lee CG , et al . Associations of 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D with bone mineral density, bone mineral density change, and incident nonvertebral fracture . J Bone Miner Res 2015 ; 30 ( 8 ): 1403 - 13 . doi: 10.1002/jbmr.2487 1001-9294-36-2-135/jbmr.2487 . DOI: 10.1002/jbmr.2487 http://doi.org/10.1002/jbmr.2487 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.2487 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.2487

Cauley JA , Parimi N , Ensrud KE , et al . Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men . J Bone Miner Res 2010 ; 25 ( 3 ): 545 - 53 . doi: 10.1359/jbmr.090826 1001-9294-36-2-135/jbmr.090826 . DOI: 10.1359/jbmr.090826 http://doi.org/10.1359/jbmr.090826

Robinson-Cohen C , Katz R , Hoofnagle AN , et al . Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study . J Clin Endocrinol Metab 2011 ; 96 ( 7 ): 2186 - 93 . doi: 10.1210/jc.2010-2878 1001-9294-36-2-135/jc.2010-2878 . DOI: 10.1210/jc.2010-2878 http://doi.org/10.1210/jc.2010-2878

Harris TB , Song X , Reinders I , et al . Plasma phospholipid fatty acids and fish-oil consumption in relation to osteoporotic fracture risk in older adults: the age, gene/environment susceptibility study . Am J Clin Nutr 2015 ; 101 ( 5 ): 947 - 55 . doi: 10.3945/ajcn.114.087502 1001-9294-36-2-135/ajcn.114.087502 . DOI: 10.3945/ajcn.114.087502 http://doi.org/10.3945/ajcn.114.087502 https://academic.oup.com/ajcn/article/101/5/947/4577556 https://academic.oup.com/ajcn/article/101/5/947/4577556

Sugimoto TNK , Kuribayashi F , Chihara K , et al . Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures . J Bone Miner Res 1997 ; 12 ( 8 ): 1272 - 9 . doi: 10.1359/jbmr.1997.12.8.1272 1001-9294-36-2-135/jbmr.1997.12.8.1272 . DOI: 10.1359/jbmr.1997.12.8.1272 http://doi.org/10.1359/jbmr.1997.12.8.1272

Nakaoka D , Sugimoto T , Kaji H , et al . Determinants of bone mineral density and spinal fracture risk in postmenopausal Japanese women . Osteoporos Int 2001 ; 12 ( 7 ): 548 - 54 . doi: 10.1007/s001980170075 1001-9294-36-2-135/s001980170075 . DOI: 10.1007/s001980170075 http://doi.org/10.1007/s001980170075

Yamaguchi T , Kanatani M , Yamauchi M , et al . Serum levels of insulin-like growth factor (IGF); IGF-binding proteins-3, -4, and -5; and their relationships to bone mineral density and the risk of vertebral fractures in postmenopausal women . Calcif Tissue Int 2006 ; 78 ( 1 ): 18 - 24 . doi: 10.1007/s00223-005-0163-z 1001-9294-36-2-135/s00223-005-0163-z . DOI: 10.1007/s00223-005-0163-z http://doi.org/10.1007/s00223-005-0163-z http://link.springer.com/10.1007/s00223-005-0163-z http://link.springer.com/10.1007/s00223-005-0163-z

Kim BJ , Rhee Y , Kim CH , et al . Plasma periostin associates significantly with non-vertebral but not vertebral fractures in postmenopausal women: clinical evidence for the different effects of periostin depending on the skeletal site . Bone 2015 ; 81 : 435 - 41 . doi: 10.1016/j.bone.2015.08.014 1001-9294-36-2-135/j.bone.2015.08.014 . DOI: 10.1016/j.bone.2015.08.014 http://doi.org/10.1016/j.bone.2015.08.014 https://linkinghub.elsevier.com/retrieve/pii/S8756328215003257 https://linkinghub.elsevier.com/retrieve/pii/S8756328215003257

Yan J , Liu HJ , Li H , et al . Circulating periostin levels increase in association with bone density loss and healing progression during the early phase of hip fracture in Chinese older women . Osteoporos Int 2017 ; 28 ( 8 ): 2335 - 41 . doi: 10.1007/s00198-017-4034-z 1001-9294-36-2-135/s00198-017-4034-z . DOI: 10.1007/s00198-017-4034-z http://doi.org/10.1007/s00198-017-4034-z

Seeliger C , Karpinski K , Haug AT , et al . Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures . J Bone Miner Res 2014 ; 29 ( 8 ): 1718 - 28 . doi: 10.1002/jbmr.2175 1001-9294-36-2-135/jbmr.2175 . DOI: 10.1002/jbmr.2175 http://doi.org/10.1002/jbmr.2175 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.2175 https://onlinelibrary.wiley.com/doi/10.1002/jbmr.2175

Panach L , Mifsut D , Tarin JJ , et al . Serum circulating microRNAs as biomarkers of osteoporotic fracture . Calcif Tissue Int 2015 ; 97 ( 5 ): 495 - 505 . doi: 10.1007/s00223-015-0036-z 1001-9294-36-2-135/s00223-015-0036-z . DOI: 10.1007/s00223-015-0036-z http://doi.org/10.1007/s00223-015-0036-z http://link.springer.com/10.1007/s00223-015-0036-z http://link.springer.com/10.1007/s00223-015-0036-z

Lian JB , Stein GS , van Wijnen AJ , et al . MicroRNA control of bone formation and homeostasis . Nat Rev Endocrinol 2012 ; 8 ( 4 ): 212 - 27 . doi: 10.1038/nrendo.2011.234 1001-9294-36-2-135/nrendo.2011.234 . DOI: 10.1038/nrendo.2011.234 http://doi.org/10.1038/nrendo.2011.234 https://doi.org/10.1038/nrendo.2011.234 https://doi.org/10.1038/nrendo.2011.234

Weilner S , Skalicky S , Salzer B , et al . Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation . Bone 2015 ; 79 : 43 - 51 . doi: 10.1016/j.bone.2015.05.027 1001-9294-36-2-135/j.bone.2015.05.027 . DOI: 10.1016/j.bone.2015.05.027 http://doi.org/10.1016/j.bone.2015.05.027

Kocijan R , Muschitz C , Geiger E , et al . Circulating microRNA signatures in patients with idiopathic and postmenopausal osteoporosis and fragility fractures . J Clin Endocrinol Metab 2016 ; 101 ( 11 ): 4125 - 34 . doi: 10.1210/jc.2016-2365 1001-9294-36-2-135/jc.2016-2365 . DOI: 10.1210/jc.2016-2365 http://doi.org/10.1210/jc.2016-2365

Li Z , Hassan MQ , Jafferji M , et al . Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation . J Biol Chem 2009 ; 284 ( 23 ): 15676 - 84 . doi: 10.1074/jbc.M809787200 1001-9294-36-2-135/jbc.M809787200 . DOI: 10.1074/jbc.M809787200 http://doi.org/10.1074/jbc.M809787200 https://linkinghub.elsevier.com/retrieve/pii/S0021925820425438 https://linkinghub.elsevier.com/retrieve/pii/S0021925820425438

Franceschetti T , Dole NS , Kessler CB , et al . Pathway analysis of microRNA expression profile during murine osteoclastogenesis . PLoS One 2014 ; 9 ( 9 ): e107262 . doi: 10.1371/journal.pone.0107262 1001-9294-36-2-135/journal.pone.0107262 . DOI: 10.1371/journal.pone.0107262 http://doi.org/10.1371/journal.pone.0107262 https://dx.plos.org/10.1371/journal.pone.0107262 https://dx.plos.org/10.1371/journal.pone.0107262

Mandourah AY , Ranganath L , Barraclough R , et al . Circulating microRNAs as potential diagnostic biomarkers for osteoporosis . Sci Rep 2018 ; 8 ( 1 ): 8421 . doi: 10.1038/s41598-018-26525-y 1001-9294-36-2-135/s41598-018-26525-y . DOI: 10.1038/s41598-018-26525-y http://doi.org/10.1038/s41598-018-26525-y

Ramirez-Salazar EG , Carrillo-Patino S , Hidalgo-Bravo A , et al . Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women . Gene 2018 ; 679 : 19 - 27 . doi: 10.1016/j.gene.2018.08.074 1001-9294-36-2-135/j.gene.2018.08.074 . DOI: 10.1016/j.gene.2018.08.074 http://doi.org/10.1016/j.gene.2018.08.074 https://linkinghub.elsevier.com/retrieve/pii/S0378111918309363 https://linkinghub.elsevier.com/retrieve/pii/S0378111918309363

Chen Z , Bemben MG , Bemben DA . Bone and muscle specific circulating microRNAs in postmenopausal women based on osteoporosis and sarcopenia status . Bone 2019 ; 120 : 271 - 8 . doi: 10.1016/j.bone.2018.11.001 1001-9294-36-2-135/j.bone.2018.11.001 . DOI: 10.1016/j.bone.2018.11.001 http://doi.org/10.1016/j.bone.2018.11.001 https://linkinghub.elsevier.com/retrieve/pii/S8756328218304228 https://linkinghub.elsevier.com/retrieve/pii/S8756328218304228

Rull MA , Cano-Garcia Mdel C , Arrabal-Martin M , et al . The importance of urinary calcium in postmenopausal women with osteoporotic fracture . Can Urol Assoc J 2015 ; 9 ( 3-4 ): E183 - 6 . doi: 10.5489/cuaj.2695 1001-9294-36-2-135/cuaj.2695 . DOI: 10.5489/cuaj.2695 http://doi.org/10.5489/cuaj.2695

Wu VC , Chang CH , Wang CY , et al . Risk of fracture in primary aldosteronism: a population-based cohort study . J Bone Miner Res 2017 ; 32 ( 4 ): 743 - 52 . doi: 10.1002/jbmr.3033 1001-9294-36-2-135/jbmr.3033 . DOI: 10.1002/jbmr.3033 http://doi.org/10.1002/jbmr.3033 http://doi.wiley.com/10.1002/jbmr.v32.4 http://doi.wiley.com/10.1002/jbmr.v32.4

Kuroda T , Tanaka S , Saito M , et al . Plasma level of homocysteine associated with severe vertebral fracture in postmenopausal women . Calcif Tissue Int 2013 ; 93 ( 3 ): 269 - 75 . doi: 10.1007/s00223-013-9754-2 1001-9294-36-2-135/s00223-013-9754-2 . DOI: 10.1007/s00223-013-9754-2 http://doi.org/10.1007/s00223-013-9754-2 http://link.springer.com/10.1007/s00223-013-9754-2 http://link.springer.com/10.1007/s00223-013-9754-2

Zhu Y , Shen J , Cheng Q , et al . Plasma homocysteine level is a risk factor for osteoporotic fractures in elderly patients . Clin Interv Aging 2016 ; 11 : 1117 - 21 . doi: 10.2147/CIA.S107868 1001-9294-36-2-135/CIA.S107868 . DOI: 10.2147/CIA.S107868 http://doi.org/10.2147/CIA.S107868 https://www.dovepress.com/clinical-interventions-in-aging-journal https://www.dovepress.com/clinical-interventions-in-aging-journal

Bahtiri E , Islami H , Rexhepi S , et al . Relationship of homocysteine levels with lumbar spine and femur neck BMD in postmenopausal women . Acta Reumatol Port 2015 ; 40 ( 4 ): 355 - 62 .

Kim BJ , Koh JM , Lee SY , et al . Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women . J Clin Endocrinol Metab 2012 ; 97 ( 10 ): 3807 - 14 . doi: 10.1210/jc.2012-2346 1001-9294-36-2-135/jc.2012-2346 . DOI: 10.1210/jc.2012-2346 http://doi.org/10.1210/jc.2012-2346 https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2012-2346 https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2012-2346

Bae SJ , Lee SH , Ahn SH , et al . The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study . Osteoporos Int 2016 ; 27 ( 8 ): 2533 - 41 . doi: 10.1007/s00198-016-3565-z 1001-9294-36-2-135/s00198-016-3565-z . DOI: 10.1007/s00198-016-3565-z http://doi.org/10.1007/s00198-016-3565-z

Navarro-Valverde C , Caballero-Villarraso J , Mata-Granados JM , et al . High serum retinol as a relevant contributor to low bone mineral density in postmenopausal osteoporotic women . Calcif Tissue Int 2018 ; 102 ( 6 ): 651 - 6 . doi: 10.1007/s00223-017-0379-8 1001-9294-36-2-135/s00223-017-0379-8 . DOI: 10.1007/s00223-017-0379-8 http://doi.org/10.1007/s00223-017-0379-8 https://doi.org/10.1007/s00223-017-0379-8 https://doi.org/10.1007/s00223-017-0379-8

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