Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study

Liu Ju; Xu Zhijian; Bi Xiaofeng; Sun Ping; Huang Jiaqin

doi:10.24920/003789

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Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study

Chinese Medical Sciences Journal Vol. 36, Issue 1, Pages: 27-34(2021)

Original Article | Updated：2024-04-10

- Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study
- Affiliations：
  
  Department of Cancer Prevention, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
- Author bio：
  
  * Zhijian Xu, E-mail: xuzj678@aliyun.com
- Funds：
- DOI：10.24920/003789
  CLC：
- Received：03 June 2020，
  
  Accepted：2020-9-15，
  
  Published Online：31 March 2021，
  
  Published：31 March 2021
- Accepted：
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Liu Ju, Xu Zhijian, Bi Xiaofeng, et al. Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study[J]. Chinese medical sciences journal, 2021, 36(1): 27-34.
DOI：

Liu Ju, Xu Zhijian, Bi Xiaofeng, et al. Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study[J]. Chinese medical sciences journal, 2021, 36(1): 27-34. DOI： 10.24920/003789.

摘要

目的

分析父母双亲和至少一个子女均患癌症的中国家庭的癌症发病特点

为制定父母均患癌症人员的早期诊断和筛查方案提供参考。

方法

从国家癌症中心的防癌体检中心自2008年1月至2018年2月间体检人员家族史数据库中搜集父亲、母亲及至少一位子女均患癌的家庭。分析患癌成员的癌症病种及所占比例、诊断年龄的分布特点

子女与父亲或母亲所患癌种及癌症所来源生理系统的相似性。将父亲组、母亲组、女儿组和儿子组中不同肿瘤的发病占比与国家癌症中心肿瘤登记办公室（NCCRC）2013年统计的全国数据进行比较。

结果

从33 200名体检人员癌症家族史数据库中共搜集135个父母双亲与子女均患癌症的家庭纳入研究。肺癌在父亲组（40/135

29.6%）和母亲组（38/135

28.1%）患癌中的占比明显高于NCCRC数据肺癌在男性（23.9%）及女性（14.9%）患癌中的占比。乳腺癌在女儿组患癌的占比（35/109

32.1%）明显高于在母亲组（14/135

10.4%）和NCCRC数据乳腺癌在女性患癌中的占比（17.1%）。71对父子中

患同种癌症的占16.9%（12/71）

患癌来源于同一系统的占46.5%（33/71）。这两个指标在109对父女中分别是31.2%（

=34）和10.1%（

=11）;在71对母子中分别为36.6%（

=26）和8.5%（

=6）;在109对母女中分别为31.2%（

=34）和20.2%（

=20）。父子患来源于同一系统的恶性肿瘤的可能性高于父女（

=4.299

0.05）

而母女患同一种恶性肿瘤的可能性高于母子（

=4.506

0.05）。罹患癌症的诊断年龄均数在儿子组[（59.4±10.9）岁]和女儿组[（52.4±12.7）岁]

明显低于父亲组[（65.5±12.2）岁]和母亲组[（65.7±12.5）岁]

（均

0.001）。

结论

父母双亲均患癌的人员在进行癌症早诊或筛查时

应进行多种癌症的全面检查

而不应仅检查与父亲或者母亲同样的恶性肿瘤或者来源于同一系统的恶性肿瘤

并且筛检的开始年龄应较针对一般人群建议的开始年龄提前。男性个体需尤其重视消化系统来源恶性肿瘤的筛检

而女性个体应重点筛查女性特有癌症（乳腺癌、卵巢癌、宫颈癌和子宫癌）

尤其应重视乳腺癌的筛查。

Abstract

Objective

To characterize Chinese families in which both parents and at least one child are diagnosed with malignant diseases and provide reference for cancer screening or early detection in people whose both parents are diagnosed with cancer.

Methods

Medical records of all clients to the center of cancer screening and prevention of the National Cancer Center/Cancer Hospital between January 2008 and February 2018 were screened to select families in which both parents and at least one child were diagnosed with malignant diseases. The cancer profiles of fathers

mothers

sons and daughters

their age distribution at diagnosis

and similarity of cancers between two generations were analyzed. The proportions of each cancer in males and females of the cohort were compared with corresponding data from the National Cancer Center Registry of China (NCCRC) in 2013.

Results

Totally 135 families were identified from records of 33 200 clients. Proportion of lung cancer in fathers (40/135

29.6%) and in mothers (38/135

28.1%) were higher than the national data (23.9% in males and 14.9% in females

respectively). The proportion of breast cancer in daughters (35/109

32.1%) was higher than that of mothers (14/135

10.4%) and the national data (17.1%). In 71 father-son pairs of cancer

46.5% (33/71) were of the same systematic disease

and 16.9% (12/71) were of the same cancer. These two indexes were 31.2% (

=34) and 10.1% (

=11)

respectively in the 109 father-daughter pairs of cancer

36.6% (

=26) and 8.5% (

=6) respectively in the 71 mother-son pairs of cancer

and 31.2% (

=34) and 20.2% (

=20) respectively in the 109 mother-daughter pairs of cancer. Sons were more likely to suffer from cancers originated from the same system as father’s cancer than daughters (

=4.299

0.05)

and daughters were more likely to suffer from the same cancer as their mother’s cancer than sons (

=4.506

0.05). The age (mean ± standard deviation) of the daughters (52.4±12.7) and the sons (59.4±10.9) at diagnosis were significantly younger than the fathers (65.5±12.2) and the mothers (65.7 ±12.5) (all

0.001).

Conclusions

For people whose both parents are diagnosed as cancer

screening or early detection examinations should cover a full range of cancers rather than the cancers their father and mother have suffered

or cancers stemmed from the same system as their parent’s cancers. We suggest screening or early detection program for these special population start earlier than that for the general population

with emphasis on cancers derived from digestive system for males and women-specific cancers

i.e.

breast cancer

ovarian cancer

cervical cancer and uterine cancer for females.

关键词

Keywords

references

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